Amniotic fluid absorbance at 650 nm: A comparison with fetal lung maturity characteristics

V. A. Khouzami, J. C. Beck, J. W C Johnson, Wayne A Mitzner, W. T. London

Research output: Contribution to journalArticle

Abstract

Using the rhesus monkey as an animal model we measured several indices of fetal lung maturation including pressure-volume characteristics and phospholipid concentrations and correlated them with the absorbance of amniotic fluid at 650 nm (A650). Those parameters, which are indicative of the presence of surfactant (i.e., deflation stability, lecithin-sphingomyelin ratio, lung phosphatidylcholine, as well as disaturated phosphatidylcholine), correlate significantly with the amniotic fluid A650, even after correction for gestational age. Maximal lung volume changes, thought to be reflective of alterations in tissue forces, did not correlate with A650. These data in the rhesus fetus indicate that the A650 reflects pulmonary surfactant characteristics independent of gestational age. Accordingly, this test may prove to be an accurate predictor of the risk of the respiratory distress syndrome.

Original languageEnglish (US)
Pages (from-to)212-216
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume141
Issue number2
StatePublished - 1981

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Amniotic Fluid
Lung
Gestational Age
Pulmonary Surfactants
Sphingomyelins
Lecithins
Macaca mulatta
Phosphatidylcholines
Surface-Active Agents
Phospholipids
Fetus
Animal Models
Pressure

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Amniotic fluid absorbance at 650 nm : A comparison with fetal lung maturity characteristics. / Khouzami, V. A.; Beck, J. C.; Johnson, J. W C; Mitzner, Wayne A; London, W. T.

In: American Journal of Obstetrics and Gynecology, Vol. 141, No. 2, 1981, p. 212-216.

Research output: Contribution to journalArticle

Khouzami, V. A. ; Beck, J. C. ; Johnson, J. W C ; Mitzner, Wayne A ; London, W. T. / Amniotic fluid absorbance at 650 nm : A comparison with fetal lung maturity characteristics. In: American Journal of Obstetrics and Gynecology. 1981 ; Vol. 141, No. 2. pp. 212-216.
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