Amnio-Allantoic fluid exchange for the prevention of intestinal damage in gastroschisis

An experimental study on chick embryos

T. Aktuǧ, Gulsun Erdag, A. Kargi, F. M. Akgür, D. Tibboel

Research output: Contribution to journalArticle

Abstract

In gastroschisis, the protruding intestine is usually shortened, thickened, and covered with a fibrous peel. Urine components, which are increased in the amniotic fluid with the onset of renal function, are responsible for these changes. In the chick embryo model of gastroschisis, the authors performed amnio-allantoic fluid exchange to reduce the effect of urinary products. There were three study groups: control, gastroschisis only, and gastroschisis plus exchange. There was a significant decrease in creatinine (P <.05) and a slight decrease in urea concentrations in the gastroschisisplus-exchange group compared with the gastroschisis-only group. Whereas macroscopic and microscopic studies showed severe fibrosis and bowel-wall thickening in the latter group, the bowel was normal or slightly oedematous in the former. On the basis of this study, the authors suggest that antenatal amniotic fluid exchange might reduce the bowel damage in human foetuses.

Original languageEnglish (US)
Pages (from-to)384-387
Number of pages4
JournalJournal of Pediatric Surgery
Volume30
Issue number3
StatePublished - Mar 1995
Externally publishedYes

Fingerprint

Gastroschisis
Chick Embryo
Amniotic Fluid
Intestines
Urea
Creatinine
Fetus
Fibrosis
Urine
Kidney
Control Groups

Keywords

  • amniotic fluid
  • foetal treatment
  • Gastroschisis

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Amnio-Allantoic fluid exchange for the prevention of intestinal damage in gastroschisis : An experimental study on chick embryos. / Aktuǧ, T.; Erdag, Gulsun; Kargi, A.; Akgür, F. M.; Tibboel, D.

In: Journal of Pediatric Surgery, Vol. 30, No. 3, 03.1995, p. 384-387.

Research output: Contribution to journalArticle

Aktuǧ, T. ; Erdag, Gulsun ; Kargi, A. ; Akgür, F. M. ; Tibboel, D. / Amnio-Allantoic fluid exchange for the prevention of intestinal damage in gastroschisis : An experimental study on chick embryos. In: Journal of Pediatric Surgery. 1995 ; Vol. 30, No. 3. pp. 384-387.
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