Amish revisited: Next-generation sequencing studies of psychiatric disorders among the Plain people

Liping Hou, Gloria Faraci, David T.W. Chen, Layla Kassem, Thomas G. Schulze, Yin Yao Shugart, Francis J. McMahon

Research output: Contribution to journalReview articlepeer-review

Abstract

The rapid development of next-generation sequencing (NGS) technology has led to renewed interest in the potential contribution of rarer forms of genetic variation to complex non-mendelian phenotypes such as psychiatric illnesses. Although challenging, family-based studies offer some advantages, especially in communities with large families and a limited number of founders. Here we revisit family-based studies of mental illnesses in traditional Amish and Mennonite communities - known collectively as the Plain people. We discuss the new opportunities for NGS in these populations, with particular emphasis on investigating psychiatric disorders. We also address some of the challenges facing NGS-based studies of complex phenotypes in founder populations.

Original languageEnglish (US)
Pages (from-to)412-418
Number of pages7
JournalTrends in Genetics
Volume29
Issue number7
DOIs
StatePublished - Jul 2013

Keywords

  • Anabaptist
  • Bipolar disorder
  • Homozygosity
  • Identity by descent
  • Mennonite

ASJC Scopus subject areas

  • Genetics

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