Amish revisited: Next-generation sequencing studies of psychiatric disorders among the Plain people

Liping Hou, Gloria Faraci, David T W Chen, Layla Kassem, Thomas G. Schulze, Yin Yao Shugart, Francis J. McMahon

Research output: Contribution to journalArticle

Abstract

The rapid development of next-generation sequencing (NGS) technology has led to renewed interest in the potential contribution of rarer forms of genetic variation to complex non-mendelian phenotypes such as psychiatric illnesses. Although challenging, family-based studies offer some advantages, especially in communities with large families and a limited number of founders. Here we revisit family-based studies of mental illnesses in traditional Amish and Mennonite communities - known collectively as the Plain people. We discuss the new opportunities for NGS in these populations, with particular emphasis on investigating psychiatric disorders. We also address some of the challenges facing NGS-based studies of complex phenotypes in founder populations.

Original languageEnglish (US)
Pages (from-to)412-418
Number of pages7
JournalTrends in Genetics
Volume29
Issue number7
DOIs
StatePublished - Jul 2013
Externally publishedYes

Fingerprint

Amish
Psychiatry
Phenotype
Population
Technology

Keywords

  • Anabaptist
  • Bipolar disorder
  • Homozygosity
  • Identity by descent
  • Mennonite

ASJC Scopus subject areas

  • Genetics

Cite this

Hou, L., Faraci, G., Chen, D. T. W., Kassem, L., Schulze, T. G., Shugart, Y. Y., & McMahon, F. J. (2013). Amish revisited: Next-generation sequencing studies of psychiatric disorders among the Plain people. Trends in Genetics, 29(7), 412-418. https://doi.org/10.1016/j.tig.2013.01.007

Amish revisited : Next-generation sequencing studies of psychiatric disorders among the Plain people. / Hou, Liping; Faraci, Gloria; Chen, David T W; Kassem, Layla; Schulze, Thomas G.; Shugart, Yin Yao; McMahon, Francis J.

In: Trends in Genetics, Vol. 29, No. 7, 07.2013, p. 412-418.

Research output: Contribution to journalArticle

Hou, L, Faraci, G, Chen, DTW, Kassem, L, Schulze, TG, Shugart, YY & McMahon, FJ 2013, 'Amish revisited: Next-generation sequencing studies of psychiatric disorders among the Plain people', Trends in Genetics, vol. 29, no. 7, pp. 412-418. https://doi.org/10.1016/j.tig.2013.01.007
Hou, Liping ; Faraci, Gloria ; Chen, David T W ; Kassem, Layla ; Schulze, Thomas G. ; Shugart, Yin Yao ; McMahon, Francis J. / Amish revisited : Next-generation sequencing studies of psychiatric disorders among the Plain people. In: Trends in Genetics. 2013 ; Vol. 29, No. 7. pp. 412-418.
@article{194d76ed2eb14d7f9b1c08868d24fd75,
title = "Amish revisited: Next-generation sequencing studies of psychiatric disorders among the Plain people",
abstract = "The rapid development of next-generation sequencing (NGS) technology has led to renewed interest in the potential contribution of rarer forms of genetic variation to complex non-mendelian phenotypes such as psychiatric illnesses. Although challenging, family-based studies offer some advantages, especially in communities with large families and a limited number of founders. Here we revisit family-based studies of mental illnesses in traditional Amish and Mennonite communities - known collectively as the Plain people. We discuss the new opportunities for NGS in these populations, with particular emphasis on investigating psychiatric disorders. We also address some of the challenges facing NGS-based studies of complex phenotypes in founder populations.",
keywords = "Anabaptist, Bipolar disorder, Homozygosity, Identity by descent, Mennonite",
author = "Liping Hou and Gloria Faraci and Chen, {David T W} and Layla Kassem and Schulze, {Thomas G.} and Shugart, {Yin Yao} and McMahon, {Francis J.}",
year = "2013",
month = "7",
doi = "10.1016/j.tig.2013.01.007",
language = "English (US)",
volume = "29",
pages = "412--418",
journal = "Trends in Genetics",
issn = "0168-9525",
publisher = "Elsevier Limited",
number = "7",

}

TY - JOUR

T1 - Amish revisited

T2 - Next-generation sequencing studies of psychiatric disorders among the Plain people

AU - Hou, Liping

AU - Faraci, Gloria

AU - Chen, David T W

AU - Kassem, Layla

AU - Schulze, Thomas G.

AU - Shugart, Yin Yao

AU - McMahon, Francis J.

PY - 2013/7

Y1 - 2013/7

N2 - The rapid development of next-generation sequencing (NGS) technology has led to renewed interest in the potential contribution of rarer forms of genetic variation to complex non-mendelian phenotypes such as psychiatric illnesses. Although challenging, family-based studies offer some advantages, especially in communities with large families and a limited number of founders. Here we revisit family-based studies of mental illnesses in traditional Amish and Mennonite communities - known collectively as the Plain people. We discuss the new opportunities for NGS in these populations, with particular emphasis on investigating psychiatric disorders. We also address some of the challenges facing NGS-based studies of complex phenotypes in founder populations.

AB - The rapid development of next-generation sequencing (NGS) technology has led to renewed interest in the potential contribution of rarer forms of genetic variation to complex non-mendelian phenotypes such as psychiatric illnesses. Although challenging, family-based studies offer some advantages, especially in communities with large families and a limited number of founders. Here we revisit family-based studies of mental illnesses in traditional Amish and Mennonite communities - known collectively as the Plain people. We discuss the new opportunities for NGS in these populations, with particular emphasis on investigating psychiatric disorders. We also address some of the challenges facing NGS-based studies of complex phenotypes in founder populations.

KW - Anabaptist

KW - Bipolar disorder

KW - Homozygosity

KW - Identity by descent

KW - Mennonite

UR - http://www.scopus.com/inward/record.url?scp=84879603242&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879603242&partnerID=8YFLogxK

U2 - 10.1016/j.tig.2013.01.007

DO - 10.1016/j.tig.2013.01.007

M3 - Article

C2 - 23422049

AN - SCOPUS:84879603242

VL - 29

SP - 412

EP - 418

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

IS - 7

ER -