Aminophylline reduces air-flow-induced constriction in the canine lung periphery

D. Wang, N Franklin Adkinson, H. A. Menkes, A. N. Freed

Research output: Contribution to journalArticle

Abstract

We examined the effect of aminophylline on air-flow-induced constriction in the canine lung periphery. A wedged bronchoscope technique was used to measure airway wall temperature (Taw) and collateral resistance (Rcs) before and after air flow was increased from a baseline flow of 200 to 500, 1,000, 1,500, or 2,000 ml/min for 2-min periods. When a sublobar segment was challenged with dry air, Taw fell during the challenge (p2, TxB2, and histamine or the cell numbers and profiles obtained by bronchoalveolar lavage performed 5 min postchallenge. However, trends were consistent with the decreased physiologic responses observed. Finally, aminophylline proved ineffective in reducing the constrictor response of peripheral lung challenged directly with aerosolized histamine or PGD2. Because preaminophylline and postaminophylline peripheral lung sensitivity (as assessed by the ratio ΔRcs/ΔTaw) were not significantly different, we conclude that aminophylline attenuates physiologic responses by reducing the strength of the stimulus. Aminophylline could do this by facilitating the replacement of heat and water removed during dry air challenge by increasing bronchial or pulmonary blood flow, or by reducing heat and water loss via changes in mucosal permeability.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalAmerican Review of Respiratory Disease
Volume137
Issue number1
StatePublished - 1988

Fingerprint

Aminophylline
Constriction
Canidae
Air
Lung
Histamine
Hot Temperature
Bronchoscopes
Prostaglandin D2
Water
Bronchoalveolar Lavage
Permeability
Cell Count
Temperature

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Aminophylline reduces air-flow-induced constriction in the canine lung periphery. / Wang, D.; Adkinson, N Franklin; Menkes, H. A.; Freed, A. N.

In: American Review of Respiratory Disease, Vol. 137, No. 1, 1988, p. 31-37.

Research output: Contribution to journalArticle

@article{a2e086f22dc24c7bb3434a7730ce6c44,
title = "Aminophylline reduces air-flow-induced constriction in the canine lung periphery",
abstract = "We examined the effect of aminophylline on air-flow-induced constriction in the canine lung periphery. A wedged bronchoscope technique was used to measure airway wall temperature (Taw) and collateral resistance (Rcs) before and after air flow was increased from a baseline flow of 200 to 500, 1,000, 1,500, or 2,000 ml/min for 2-min periods. When a sublobar segment was challenged with dry air, Taw fell during the challenge (p2, TxB2, and histamine or the cell numbers and profiles obtained by bronchoalveolar lavage performed 5 min postchallenge. However, trends were consistent with the decreased physiologic responses observed. Finally, aminophylline proved ineffective in reducing the constrictor response of peripheral lung challenged directly with aerosolized histamine or PGD2. Because preaminophylline and postaminophylline peripheral lung sensitivity (as assessed by the ratio ΔRcs/ΔTaw) were not significantly different, we conclude that aminophylline attenuates physiologic responses by reducing the strength of the stimulus. Aminophylline could do this by facilitating the replacement of heat and water removed during dry air challenge by increasing bronchial or pulmonary blood flow, or by reducing heat and water loss via changes in mucosal permeability.",
author = "D. Wang and Adkinson, {N Franklin} and Menkes, {H. A.} and Freed, {A. N.}",
year = "1988",
language = "English (US)",
volume = "137",
pages = "31--37",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "1",

}

TY - JOUR

T1 - Aminophylline reduces air-flow-induced constriction in the canine lung periphery

AU - Wang, D.

AU - Adkinson, N Franklin

AU - Menkes, H. A.

AU - Freed, A. N.

PY - 1988

Y1 - 1988

N2 - We examined the effect of aminophylline on air-flow-induced constriction in the canine lung periphery. A wedged bronchoscope technique was used to measure airway wall temperature (Taw) and collateral resistance (Rcs) before and after air flow was increased from a baseline flow of 200 to 500, 1,000, 1,500, or 2,000 ml/min for 2-min periods. When a sublobar segment was challenged with dry air, Taw fell during the challenge (p2, TxB2, and histamine or the cell numbers and profiles obtained by bronchoalveolar lavage performed 5 min postchallenge. However, trends were consistent with the decreased physiologic responses observed. Finally, aminophylline proved ineffective in reducing the constrictor response of peripheral lung challenged directly with aerosolized histamine or PGD2. Because preaminophylline and postaminophylline peripheral lung sensitivity (as assessed by the ratio ΔRcs/ΔTaw) were not significantly different, we conclude that aminophylline attenuates physiologic responses by reducing the strength of the stimulus. Aminophylline could do this by facilitating the replacement of heat and water removed during dry air challenge by increasing bronchial or pulmonary blood flow, or by reducing heat and water loss via changes in mucosal permeability.

AB - We examined the effect of aminophylline on air-flow-induced constriction in the canine lung periphery. A wedged bronchoscope technique was used to measure airway wall temperature (Taw) and collateral resistance (Rcs) before and after air flow was increased from a baseline flow of 200 to 500, 1,000, 1,500, or 2,000 ml/min for 2-min periods. When a sublobar segment was challenged with dry air, Taw fell during the challenge (p2, TxB2, and histamine or the cell numbers and profiles obtained by bronchoalveolar lavage performed 5 min postchallenge. However, trends were consistent with the decreased physiologic responses observed. Finally, aminophylline proved ineffective in reducing the constrictor response of peripheral lung challenged directly with aerosolized histamine or PGD2. Because preaminophylline and postaminophylline peripheral lung sensitivity (as assessed by the ratio ΔRcs/ΔTaw) were not significantly different, we conclude that aminophylline attenuates physiologic responses by reducing the strength of the stimulus. Aminophylline could do this by facilitating the replacement of heat and water removed during dry air challenge by increasing bronchial or pulmonary blood flow, or by reducing heat and water loss via changes in mucosal permeability.

UR - http://www.scopus.com/inward/record.url?scp=0023834894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023834894&partnerID=8YFLogxK

M3 - Article

C2 - 3422143

AN - SCOPUS:0023834894

VL - 137

SP - 31

EP - 37

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 1

ER -