Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A

Vasudha Sharma, Gilbert T. Kelly, Jennifer Foulke-Abel, Coran M.H. Watanabe

Research output: Contribution to journalArticlepeer-review

Abstract

Experiments reveal that the metabolic precursor aminoacetone is a key intermediate in the production of the antitumor agent azinomycin A relative to the structurally and functionally related agent, azinomycin B. Azinomycin A and B arise through bifurcation of the biosynthetic pathway and competition between metabolic substrates. The availability of the biosynthetic precursors in vivo, aminoacetone for azinomycin A and threonine for azinomycin B, controls the overall ratio of azinomycin A to B produced.

Original languageEnglish (US)
Pages (from-to)4006-4009
Number of pages4
JournalOrganic Letters
Volume11
Issue number17
DOIs
StatePublished - Sep 3 2009
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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