Amino acid neurotransmitter candidates: Sodium-dependent high-affinity uptake by unique synaptosomal fractions

James P. Bennett, William J. Logan, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

Glutamic and aspartic acids and glycine are accumulated by high-affinity uptake systems into synaptosomal preparations in central nervous tissue. Sodium is required by these high-affinity transports, but not by the low-affinity transports for these and other amino acids. The sodium-requiring amino acid uptake systems label unique synaptosomal fractions. Observations suggest that these amino acids serve specific synoptic functions, presumably as neurotransmitters.

Original languageEnglish (US)
Pages (from-to)997-999
Number of pages3
JournalScience
Volume178
Issue number4064
DOIs
StatePublished - Jan 1 1972

ASJC Scopus subject areas

  • General

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