Abstract
Alterations in Zn2+ concentration are seen in normal tissues and in disease states, and for this reason imaging of Zn2+ is an area of active investigation. Herein, enriched [1-13C]cysteine and [1-13C2]iminodiacetic acid were developed as Zn2+-specific imaging probes using hyperpolarized 13C magnetic resonance spectroscopy. [1-13C]cysteine was used to accurately quantify Zn2+ in complex biological mixtures. These sensors can be employed to detect Zn2+ via imaging mechanisms including changes in 13C chemical shift, resonance linewidth, or T1.
Original language | English (US) |
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Pages (from-to) | 11842-11846 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 25 |
Issue number | 51 |
DOIs | |
State | Published - Sep 12 2019 |
Keywords
- chemical shifts
- hyperpolarization
- imaging agents
- magnetic resonance imaging
- zinc
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry