Amino Acid-Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13C Magnetic Resonance Spectroscopy

Sinan Wang; David E. Korenchan; Paola M. Perez; Céline Taglang; Thomas R. Hayes; Renuka Sriram; Robert Bok; Andrew S. Hong; Yunkou Wu; Henry Li; Zhen Wang; John Kurhanewicz; David M. Wilson; Robert R. Flavell

doi:10.1002/chem.201902771

Amino Acid-Derived Sensors for Specific Zn²⁺ Detection Using Hyperpolarized ¹³C Magnetic Resonance Spectroscopy

Sinan Wang, David E. Korenchan, Paola M. Perez, Céline Taglang, Thomas R. Hayes, Renuka Sriram, Robert Bok, Andrew S. Hong, Yunkou Wu, Henry Li, Zhen Wang, John Kurhanewicz, David M. Wilson, Robert R. Flavell

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Alterations in Zn²⁺ concentration are seen in normal tissues and in disease states, and for this reason imaging of Zn²⁺ is an area of active investigation. Herein, enriched [1-¹³C]cysteine and [1-¹³C₂]iminodiacetic acid were developed as Zn²⁺-specific imaging probes using hyperpolarized ¹³C magnetic resonance spectroscopy. [1-¹³C]cysteine was used to accurately quantify Zn²⁺ in complex biological mixtures. These sensors can be employed to detect Zn²⁺ via imaging mechanisms including changes in ¹³C chemical shift, resonance linewidth, or T₁.

Original language	English (US)
Pages (from-to)	11842-11846
Number of pages	5
Journal	Chemistry - A European Journal
Volume	25
Issue number	51
DOIs	https://doi.org/10.1002/chem.201902771
State	Published - Sep 12 2019

Keywords

chemical shifts
hyperpolarization
imaging agents
magnetic resonance imaging
zinc

ASJC Scopus subject areas

Catalysis
Organic Chemistry

Access to Document

10.1002/chem.201902771

Cite this

Wang, S., Korenchan, D. E., Perez, P. M., Taglang, C., Hayes, T. R., Sriram, R., Bok, R., Hong, A. S., Wu, Y., Li, H., Wang, Z., Kurhanewicz, J., Wilson, D. M., & Flavell, R. R. (2019). Amino Acid-Derived Sensors for Specific Zn²⁺ Detection Using Hyperpolarized ¹³C Magnetic Resonance Spectroscopy. Chemistry - A European Journal, 25(51), 11842-11846. https://doi.org/10.1002/chem.201902771

Wang, S, Korenchan, DE, Perez, PM, Taglang, C, Hayes, TR, Sriram, R, Bok, R, Hong, AS, Wu, Y, Li, H, Wang, Z, Kurhanewicz, J, Wilson, DM & Flavell, RR 2019, 'Amino Acid-Derived Sensors for Specific Zn²⁺ Detection Using Hyperpolarized ¹³C Magnetic Resonance Spectroscopy', Chemistry - A European Journal, vol. 25, no. 51, pp. 11842-11846. https://doi.org/10.1002/chem.201902771

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abstract = "Alterations in Zn2+ concentration are seen in normal tissues and in disease states, and for this reason imaging of Zn2+ is an area of active investigation. Herein, enriched [1-13C]cysteine and [1-13C2]iminodiacetic acid were developed as Zn2+-specific imaging probes using hyperpolarized 13C magnetic resonance spectroscopy. [1-13C]cysteine was used to accurately quantify Zn2+ in complex biological mixtures. These sensors can be employed to detect Zn2+ via imaging mechanisms including changes in 13C chemical shift, resonance linewidth, or T1.",

keywords = "chemical shifts, hyperpolarization, imaging agents, magnetic resonance imaging, zinc",

author = "Sinan Wang and Korenchan, {David E.} and Perez, {Paola M.} and C{\'e}line Taglang and Hayes, {Thomas R.} and Renuka Sriram and Robert Bok and Hong, {Andrew S.} and Yunkou Wu and Henry Li and Zhen Wang and John Kurhanewicz and Wilson, {David M.} and Flavell, {Robert R.}",

note = "Funding Information: R.R.F. acknowledges a Howard S. Stern award of the Society of Abdominal Radiology, a David Blitzer Prostate Cancer Foundation Young Investigator Award, a Department of Defense Prostate Cancer Research Program Physician Research Training Award, and NIH R21 EB026012-01. Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

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month = sep,

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doi = "10.1002/chem.201902771",

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AU - Wang, Sinan

AU - Korenchan, David E.

AU - Perez, Paola M.

AU - Taglang, Céline

AU - Hayes, Thomas R.

AU - Sriram, Renuka

AU - Bok, Robert

AU - Hong, Andrew S.

AU - Wu, Yunkou

AU - Li, Henry

AU - Wang, Zhen

AU - Kurhanewicz, John

AU - Wilson, David M.

AU - Flavell, Robert R.

N1 - Funding Information: R.R.F. acknowledges a Howard S. Stern award of the Society of Abdominal Radiology, a David Blitzer Prostate Cancer Foundation Young Investigator Award, a Department of Defense Prostate Cancer Research Program Physician Research Training Award, and NIH R21 EB026012-01. Publisher Copyright: © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2019/9/12

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