Amino Acid-Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13C Magnetic Resonance Spectroscopy

Sinan Wang, David E. Korenchan, Paola M. Perez, Céline Taglang, Thomas R. Hayes, Renuka Sriram, Robert Bok, Andrew S. Hong, Yunkou Wu, Henry Li, Zhen Wang, John Kurhanewicz, David M. Wilson, Robert R. Flavell

Research output: Contribution to journalArticle

Abstract

Alterations in Zn2+ concentration are seen in normal tissues and in disease states, and for this reason imaging of Zn2+ is an area of active investigation. Herein, enriched [1-13C]cysteine and [1-13C2]iminodiacetic acid were developed as Zn2+-specific imaging probes using hyperpolarized 13C magnetic resonance spectroscopy. [1-13C]cysteine was used to accurately quantify Zn2+ in complex biological mixtures. These sensors can be employed to detect Zn2+ via imaging mechanisms including changes in 13C chemical shift, resonance linewidth, or T1.

Original languageEnglish (US)
Pages (from-to)11842-11846
Number of pages5
JournalChemistry - A European Journal
Volume25
Issue number51
DOIs
StatePublished - Sep 12 2019

Keywords

  • chemical shifts
  • hyperpolarization
  • imaging agents
  • magnetic resonance imaging
  • zinc

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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    Wang, S., Korenchan, D. E., Perez, P. M., Taglang, C., Hayes, T. R., Sriram, R., Bok, R., Hong, A. S., Wu, Y., Li, H., Wang, Z., Kurhanewicz, J., Wilson, D. M., & Flavell, R. R. (2019). Amino Acid-Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13C Magnetic Resonance Spectroscopy. Chemistry - A European Journal, 25(51), 11842-11846. https://doi.org/10.1002/chem.201902771