Amino acid composition in parenteral nutrition: What is the evidence?

Shadi S. Yarandi, Vivian M. Zhao, Gautam Hebbar, Thomas R. Ziegler

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Purpose of review: Complete parenteral nutrition solutions contain mixed amino acid products providing all nine essential amino acids and a varying composition of nonessential amino acids. Relatively little rigorous comparative efficacy research on altered parenteral nutrition amino acid composition has been published in recent years. Recent findings: Limited data from randomized, double-blind, adequately powered clinical trials to define optimal doses of total or individual amino acids in parenteral nutrition are available. An exception is the growing number of studies on the efficacy of glutamine supplementation of parenteral nutrition or given as a single parenteral agent. Parenteral glutamine appears to confer benefit in selected patients; however, additional data to define optimal glutamine dosing and the patient subgroups who may most benefit from this amino acid are needed. Although some promising studies have been published, little data are available in the current era of nutrition support on the clin cal efficacy of altered doses of arginine, branched chain amino acids, cysteine, or taurine supplementation of parenteral nutrition. Summary: Despite routine use of parenteral nutrition, surprisingly little clinical efficacy data are available to guide total or specific amino acid dosing in adult and pediatric patients requiring this therapy. This warrants increased attention by the research community and funding agencies to better define optimal amino acid administration strategies in patient subgroups requiring parenteral nutrition.

Original languageEnglish (US)
Pages (from-to)75-82
Number of pages8
JournalCurrent opinion in clinical nutrition and metabolic care
Issue number1
StatePublished - Jan 2011


  • Amino acids
  • Arginine
  • Cysteine
  • Glutamine
  • Taurine

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


Dive into the research topics of 'Amino acid composition in parenteral nutrition: What is the evidence?'. Together they form a unique fingerprint.

Cite this