Amikacin + ceftazidime therapy of experimental right-sided Pseudomonas aeruginosa endocarditis in rabbits

A. S. Bayer, K. Lam, D. Norman, Kwang Sik Kim, J. O. Morrison

Research output: Contribution to journalArticle

Abstract

We investigated the efficacy of a potent new antipseudomonal β-lactam agent, ceftazidime, in a model of right-sided Pseudomonas endocarditis in 72 rabbits. Animals received either: no therapy (controls), amikacin (15 mg/kg/day), ceftazidime (100 mg/kg/day) or amikacin + ceftazidime. Amikacin + ceftazidime was significantly more effective than single-drug regimens in terms of reduction of mortality (p

Original languageEnglish (US)
Pages (from-to)351-361
Number of pages11
JournalChemotherapy
Volume31
Issue number5
StatePublished - 1985
Externally publishedYes

Fingerprint

Investigational Therapies
Ceftazidime
Amikacin
Endocarditis
Pseudomonas aeruginosa
Rabbits
Lactams
Pseudomonas
Mortality
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Amikacin + ceftazidime therapy of experimental right-sided Pseudomonas aeruginosa endocarditis in rabbits. / Bayer, A. S.; Lam, K.; Norman, D.; Kim, Kwang Sik; Morrison, J. O.

In: Chemotherapy, Vol. 31, No. 5, 1985, p. 351-361.

Research output: Contribution to journalArticle

Bayer, AS, Lam, K, Norman, D, Kim, KS & Morrison, JO 1985, 'Amikacin + ceftazidime therapy of experimental right-sided Pseudomonas aeruginosa endocarditis in rabbits', Chemotherapy, vol. 31, no. 5, pp. 351-361.
Bayer, A. S. ; Lam, K. ; Norman, D. ; Kim, Kwang Sik ; Morrison, J. O. / Amikacin + ceftazidime therapy of experimental right-sided Pseudomonas aeruginosa endocarditis in rabbits. In: Chemotherapy. 1985 ; Vol. 31, No. 5. pp. 351-361.
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