Amide proton transfer-weighted imaging of the head and neck at 3 T: A feasibility study on healthy human subjects and patients with head and neck cancer

Jing Yuan, Shuzhong Chen, Ann D. King, Jinyuan Zhou, Kunwar S. Bhatia, Qinwei Zhang, David Ka Wei Yeung, Juan Wei, Greta Seng Peng Mok, Yi Xiang Wang

Research output: Contribution to journalArticle

Abstract

The aim of this study was to explore the feasibility and repeatability of amide proton transfer-weighted (APTw) MRI for the head and neck on clinical MRI scanners. Six healthy volunteers and four patients with head and neck tumors underwent APTw MRI scanning at 3 T. The APTw signal was quantified by the asymmetric magnetization transfer ratio (MTRasym) at 3.5 ppm. Z spectra of normal tissues in the head and neck (masseter muscle, parotid glands, submandibular glands and thyroid glands) were analyzed in healthy volunteers. Inter-scan repeatability of APTw MRI was evaluated in six healthy volunteers. Z spectra of patients with head and neck tumors were produced and APTw signals in these tumors were analyzed. APTw MRI scanning was successful for all 10 subjects. The parotid glands showed the highest APTw signal (~7.6% average), whereas the APTw signals in other tissues were relatively moderate. The repeatability of APTw signals from the masseter muscle, parotid gland, submandibular gland and thyroid gland of healthy volunteers was established. Four head and neck tumors showed positive mean APTw ranging from 1.2% to 3.2%, distinguishable from surrounding normal tissues. APTw MRI was feasible for use in the head and neck regions at 3 T. The preliminary results on patients with head and neck tumors indicated the potential of APTw MRI for clinical applications.

Original languageEnglish (US)
Pages (from-to)1239-1247
Number of pages9
JournalNMR in Biomedicine
Volume27
Issue number10
DOIs
StatePublished - 2014

Fingerprint

Proton transfer
Feasibility Studies
Head and Neck Neoplasms
Amides
Protons
Healthy Volunteers
Neck
Head
Imaging techniques
Magnetic resonance imaging
Tumors
Parotid Gland
Masseter Muscle
Submandibular Gland
Neoplasms
Tissue
Muscle
Thyroid Gland
Scanning
Neck Muscles

Keywords

  • Amide proton transfer (APT)
  • Asymmetric magnetization transfer ratio
  • Chemical exchange saturation transfer (CEST)
  • Head and neck tumor
  • Parotid gland

ASJC Scopus subject areas

  • Spectroscopy
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Amide proton transfer-weighted imaging of the head and neck at 3 T : A feasibility study on healthy human subjects and patients with head and neck cancer. / Yuan, Jing; Chen, Shuzhong; King, Ann D.; Zhou, Jinyuan; Bhatia, Kunwar S.; Zhang, Qinwei; Yeung, David Ka Wei; Wei, Juan; Mok, Greta Seng Peng; Wang, Yi Xiang.

In: NMR in Biomedicine, Vol. 27, No. 10, 2014, p. 1239-1247.

Research output: Contribution to journalArticle

Yuan, Jing ; Chen, Shuzhong ; King, Ann D. ; Zhou, Jinyuan ; Bhatia, Kunwar S. ; Zhang, Qinwei ; Yeung, David Ka Wei ; Wei, Juan ; Mok, Greta Seng Peng ; Wang, Yi Xiang. / Amide proton transfer-weighted imaging of the head and neck at 3 T : A feasibility study on healthy human subjects and patients with head and neck cancer. In: NMR in Biomedicine. 2014 ; Vol. 27, No. 10. pp. 1239-1247.
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AB - The aim of this study was to explore the feasibility and repeatability of amide proton transfer-weighted (APTw) MRI for the head and neck on clinical MRI scanners. Six healthy volunteers and four patients with head and neck tumors underwent APTw MRI scanning at 3 T. The APTw signal was quantified by the asymmetric magnetization transfer ratio (MTRasym) at 3.5 ppm. Z spectra of normal tissues in the head and neck (masseter muscle, parotid glands, submandibular glands and thyroid glands) were analyzed in healthy volunteers. Inter-scan repeatability of APTw MRI was evaluated in six healthy volunteers. Z spectra of patients with head and neck tumors were produced and APTw signals in these tumors were analyzed. APTw MRI scanning was successful for all 10 subjects. The parotid glands showed the highest APTw signal (~7.6% average), whereas the APTw signals in other tissues were relatively moderate. The repeatability of APTw signals from the masseter muscle, parotid gland, submandibular gland and thyroid gland of healthy volunteers was established. Four head and neck tumors showed positive mean APTw ranging from 1.2% to 3.2%, distinguishable from surrounding normal tissues. APTw MRI was feasible for use in the head and neck regions at 3 T. The preliminary results on patients with head and neck tumors indicated the potential of APTw MRI for clinical applications.

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