Amide proton transfer MR imaging at 3. 0 T of the basal ganglia in Parkinson's disease

Rui Wang, Chunmei Li, Min Chen, Chen Zhang, Jinyuan Zhou, Wen Su

Research output: Contribution to journalArticle

Abstract

Objective: To explore the feasibility of amide proton transfer (APT) MR imaging for the detection of basal ganglia abnormalities in patients with Parkinson' s disease (PD). Methods: Twenty-seven patients with PD and twenty-three age-matched normal control subjects underwent cerebral APT and structural MR imaging. The magnetic resonance ratio asymmetry (MTRasym) values at 3.5 ppm of bilateral globus pallidus, putamen and caudate were measured on APT images. MTRasym (3.5 ppm) values of cerebral structures between PD patients and control subjects were compared with independent-samples t test. Paired-samples t test was used to compare the difference of MTRasym (3.5 ppm) between the side of onset and contralateral side in patients with PD. The difference of MTRasym (3.5 ppm) among normal controls, early-stage PD, and advanced-stage PD patients was assessed with one-way analysis of variance. Results: Compared to normal controls, MTRasym(3.5 ppm) values of globus pallidus, putamen and caudate were significantly increased in PD patients ((0.89 ± 0.12)% vs (0.57 ± 0.16)%, (1.05 ± 0.11)% vs (0.82 ± 0.15)%, (1.15 ± 0.13)% vs (0.78 ± 0.19)%; t = 3.311, 2.562, 3.277 respectively, all P values

Original languageEnglish (US)
Pages (from-to)40-43
Number of pages4
JournalChinese Journal of Neurology
Volume48
Issue number1
DOIs
StatePublished - Jan 8 2015

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Basal Ganglia
Amides
Parkinson Disease
Protons
Magnetic Resonance Spectroscopy
Globus Pallidus
Putamen
Analysis of Variance

Keywords

  • Amide proton transfer
  • Basal ganglia
  • Magnetic resonance imaging
  • Parkinson disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Amide proton transfer MR imaging at 3. 0 T of the basal ganglia in Parkinson's disease. / Wang, Rui; Li, Chunmei; Chen, Min; Zhang, Chen; Zhou, Jinyuan; Su, Wen.

In: Chinese Journal of Neurology, Vol. 48, No. 1, 08.01.2015, p. 40-43.

Research output: Contribution to journalArticle

Wang, Rui ; Li, Chunmei ; Chen, Min ; Zhang, Chen ; Zhou, Jinyuan ; Su, Wen. / Amide proton transfer MR imaging at 3. 0 T of the basal ganglia in Parkinson's disease. In: Chinese Journal of Neurology. 2015 ; Vol. 48, No. 1. pp. 40-43.
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