Amide proton transfer contrast distribution in different brain regions in young healthy subjects

Thomas Sartoretti, Elisabeth Sartoretti, Michael Wyss, Árpád Schwenk, Arash Najafi, Christoph Binkert, Carolin Reischauer, Jinyuan Zhou, Shanshan Jiang, Anton S. Becker, Sabine Sartoretti-Schefer

Research output: Contribution to journalArticle

Abstract

Objectives: To define normal signal intensity values of amide proton transfer-weighted (APTw) magnetic resonance (MR) imaging in different brain regions. Materials and Methods: Twenty healthy subjects (9 females, mean age 29 years, range 19 - 37 years) underwent MR imaging at 3 Tesla. 3D APTw (RF saturation B1,rms = 2 μT, duration 2 s, 100% duty cycle) and 2D T2-weighted turbo spin echo (TSE) images were acquired. Postprocessing (image fusion, ROI measurements of APTw intensity values in 22 different brain regions) was performed and controlled by two independent neuroradiologists. Values were measured separately for each brain hemisphere. A subject was scanned both in prone and supine position to investigate differences between hemispheres. A mixed model on a 5% significance level was used to assess the effect of gender, brain region and side on APTw intensity values. Results: Mean APTw intensity values in the hippocampus and amygdala varied between 1.13 and 1.57%, in the deep subcortical nuclei (putamen, globus pallidus, head of caudate nucleus, thalamus, red nucleus, substantia nigra) between 0.73 and 1.84%, in the frontal, occipital and parietal cortex between 0.56 and 1.03%; in the insular cortex between 1.11 and 1.15%, in the temporal cortex between 1.22 and 1.37%, in the frontal, occipital and parietal white matter between 0.32 and 0.54% and in the temporal white matter between 0.83 and 0.89%. APTw intensity values were significantly impacted both by brain region (p < 0.001) and by side (p < 0.001), whereby overall values on the left side were higher than on the right side (1.13 vs. 0.9%). Gender did not significantly impact APTw intensity values (p = 0.24). APTw intensity values between the left and the right side were partially reversed after changing the position of one subject from supine to prone. Conclusion: We determined normal baseline APTw intensity values in different anatomical localizations in healthy subjects. APTw intensity values differed both between anatomical regions and between left and right brain hemisphere.

Original languageEnglish (US)
Article number520
JournalFrontiers in Neuroscience
Volume13
Issue numberMAY
DOIs
StatePublished - Jan 1 2019

Fingerprint

Amides
Protons
Healthy Volunteers
Brain
Magnetic Resonance Imaging
Red Nucleus
Occipital Lobe
Prone Position
Parietal Lobe
Globus Pallidus
Caudate Nucleus
Putamen
Supine Position
Frontal Lobe
Substantia Nigra
Temporal Lobe
Amygdala
Thalamus
Cerebral Cortex
Hippocampus

Keywords

  • Amide proton transfer-weighted magnetic resonance imaging
  • Brain
  • Magnetic resonance imaging
  • Molecular imaging
  • Normal amide proton transfer-weighted signal intensity values

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sartoretti, T., Sartoretti, E., Wyss, M., Schwenk, Á., Najafi, A., Binkert, C., ... Sartoretti-Schefer, S. (2019). Amide proton transfer contrast distribution in different brain regions in young healthy subjects. Frontiers in Neuroscience, 13(MAY), [520]. https://doi.org/10.3389/fnins.2019.00520

Amide proton transfer contrast distribution in different brain regions in young healthy subjects. / Sartoretti, Thomas; Sartoretti, Elisabeth; Wyss, Michael; Schwenk, Árpád; Najafi, Arash; Binkert, Christoph; Reischauer, Carolin; Zhou, Jinyuan; Jiang, Shanshan; Becker, Anton S.; Sartoretti-Schefer, Sabine.

In: Frontiers in Neuroscience, Vol. 13, No. MAY, 520, 01.01.2019.

Research output: Contribution to journalArticle

Sartoretti, T, Sartoretti, E, Wyss, M, Schwenk, Á, Najafi, A, Binkert, C, Reischauer, C, Zhou, J, Jiang, S, Becker, AS & Sartoretti-Schefer, S 2019, 'Amide proton transfer contrast distribution in different brain regions in young healthy subjects', Frontiers in Neuroscience, vol. 13, no. MAY, 520. https://doi.org/10.3389/fnins.2019.00520
Sartoretti, Thomas ; Sartoretti, Elisabeth ; Wyss, Michael ; Schwenk, Árpád ; Najafi, Arash ; Binkert, Christoph ; Reischauer, Carolin ; Zhou, Jinyuan ; Jiang, Shanshan ; Becker, Anton S. ; Sartoretti-Schefer, Sabine. / Amide proton transfer contrast distribution in different brain regions in young healthy subjects. In: Frontiers in Neuroscience. 2019 ; Vol. 13, No. MAY.
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abstract = "Objectives: To define normal signal intensity values of amide proton transfer-weighted (APTw) magnetic resonance (MR) imaging in different brain regions. Materials and Methods: Twenty healthy subjects (9 females, mean age 29 years, range 19 - 37 years) underwent MR imaging at 3 Tesla. 3D APTw (RF saturation B1,rms = 2 μT, duration 2 s, 100{\%} duty cycle) and 2D T2-weighted turbo spin echo (TSE) images were acquired. Postprocessing (image fusion, ROI measurements of APTw intensity values in 22 different brain regions) was performed and controlled by two independent neuroradiologists. Values were measured separately for each brain hemisphere. A subject was scanned both in prone and supine position to investigate differences between hemispheres. A mixed model on a 5{\%} significance level was used to assess the effect of gender, brain region and side on APTw intensity values. Results: Mean APTw intensity values in the hippocampus and amygdala varied between 1.13 and 1.57{\%}, in the deep subcortical nuclei (putamen, globus pallidus, head of caudate nucleus, thalamus, red nucleus, substantia nigra) between 0.73 and 1.84{\%}, in the frontal, occipital and parietal cortex between 0.56 and 1.03{\%}; in the insular cortex between 1.11 and 1.15{\%}, in the temporal cortex between 1.22 and 1.37{\%}, in the frontal, occipital and parietal white matter between 0.32 and 0.54{\%} and in the temporal white matter between 0.83 and 0.89{\%}. APTw intensity values were significantly impacted both by brain region (p < 0.001) and by side (p < 0.001), whereby overall values on the left side were higher than on the right side (1.13 vs. 0.9{\%}). Gender did not significantly impact APTw intensity values (p = 0.24). APTw intensity values between the left and the right side were partially reversed after changing the position of one subject from supine to prone. Conclusion: We determined normal baseline APTw intensity values in different anatomical localizations in healthy subjects. APTw intensity values differed both between anatomical regions and between left and right brain hemisphere.",
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AU - Wyss, Michael

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AU - Najafi, Arash

AU - Binkert, Christoph

AU - Reischauer, Carolin

AU - Zhou, Jinyuan

AU - Jiang, Shanshan

AU - Becker, Anton S.

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N2 - Objectives: To define normal signal intensity values of amide proton transfer-weighted (APTw) magnetic resonance (MR) imaging in different brain regions. Materials and Methods: Twenty healthy subjects (9 females, mean age 29 years, range 19 - 37 years) underwent MR imaging at 3 Tesla. 3D APTw (RF saturation B1,rms = 2 μT, duration 2 s, 100% duty cycle) and 2D T2-weighted turbo spin echo (TSE) images were acquired. Postprocessing (image fusion, ROI measurements of APTw intensity values in 22 different brain regions) was performed and controlled by two independent neuroradiologists. Values were measured separately for each brain hemisphere. A subject was scanned both in prone and supine position to investigate differences between hemispheres. A mixed model on a 5% significance level was used to assess the effect of gender, brain region and side on APTw intensity values. Results: Mean APTw intensity values in the hippocampus and amygdala varied between 1.13 and 1.57%, in the deep subcortical nuclei (putamen, globus pallidus, head of caudate nucleus, thalamus, red nucleus, substantia nigra) between 0.73 and 1.84%, in the frontal, occipital and parietal cortex between 0.56 and 1.03%; in the insular cortex between 1.11 and 1.15%, in the temporal cortex between 1.22 and 1.37%, in the frontal, occipital and parietal white matter between 0.32 and 0.54% and in the temporal white matter between 0.83 and 0.89%. APTw intensity values were significantly impacted both by brain region (p < 0.001) and by side (p < 0.001), whereby overall values on the left side were higher than on the right side (1.13 vs. 0.9%). Gender did not significantly impact APTw intensity values (p = 0.24). APTw intensity values between the left and the right side were partially reversed after changing the position of one subject from supine to prone. Conclusion: We determined normal baseline APTw intensity values in different anatomical localizations in healthy subjects. APTw intensity values differed both between anatomical regions and between left and right brain hemisphere.

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