American Indian chronic Renal insufficiency cohort study (AI-CRIC study)

Mark L. Unruh, Soraya Arzhan, Harold I. Feldman, Helen C. Looker, Robert G. Nelson, Thomas Faber, David Johnson, Linda Son-Stone, Vernon S. Pankratz, Larissa Myaskovsky, Vallabh O. Shah, Lawrence J. Appel, Alan S. Go, Jiang He, James P. Lash, Mahboob Rahman, Panduranga S. Rao, Raymond R. Townsend

Research output: Contribution to journalArticlepeer-review


Background: Chronic kidney disease (CKD) is an increasing epidemic globally that is associated with adverse health outcomes including end stage kidney disease (ESKD), cardiovascular disease (CVD), and death. American Indians (AIs) have a higher prevalence of CKD than most other racial/ethnic groups, due in part to a high prevalence of type 2 diabetes. Other genetic and environmental factors not yet identified may also contribute to the disproportionate burden of CKD in AIs. Method: We will establish 3 clinical centers to recruit AIs from the Southwest United States (US) to expand the Chronic Renal Insufficiency Cohort (CRIC) study. We will follow the current CRIC protocol for kidney and cardiovascular measures and outcomes, which include ambulatory monitoring of kidney function and the use of mobile health technologies for CVD sub-phenotyping, and compare the outcomes in AIs with those in other racial/ethnic groups in CRIC. Discussion: AI-CRIC will identify the role of various risk factors for rapid loss of kidney function among AIs of the Southwest US. In addition, to better understand the natural history of CKD and CVD in this high-risk population, we will identify unique risk factors for CKD and CVD progression in AIs. We will also compare event rates and risk factors for kidney and cardiovascular events in AIs with the other populations represented in CRIC.

Original languageEnglish (US)
Article number291
JournalBMC nephrology
Issue number1
StatePublished - Jul 22 2020


  • American Indians
  • Cardiovascular disease
  • Chronic kidney disease
  • End stage Renal disease
  • Environmental exposure
  • Heart rate variability
  • eGFR

ASJC Scopus subject areas

  • Nephrology


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