TY - JOUR
T1 - Ambient air pollution alters heart rate regulation in aged mice
AU - Ramos-Bonilla, Juan P.
AU - Breysse, Patrick N.
AU - Dominici, Francesca
AU - Geyh, Alison
AU - Tankersley, Clarke G.
N1 - Funding Information:
This work was supported by the National Institute of Aging (AG-21057), the National Institute of Environmental Health Sciences (NIEHS) (PO1 ES 009606) (P50 ES 015903), US Environmental Protection Agency (R-32139), and the Johns Hopkins NIEHS Center in Urban Environmental Health (P30 ES 03819). Although the research described in this article has been funded wholly or in part by the United States Environmental Protection Agency through grant/cooperative agreement RD-83241701 to Dr. Jonathan Samet, it has not been subjected to the Agency’s required peer and policy review and therefore does not necessarily reflect the views of the Agency and no official endorsement should be inferred.
Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/3
Y1 - 2010/3
N2 - Context: Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. Objective: Determine the association at different time-lags between the complex mixture of ambient concentrations of PM, carbon monoxide (CO), and nitrogen dioxide (NO2), and markers of cardiac function in a model of aged mice. Materials and methods: AKR/J inbred mice were exposed to ambient air, 6h daily for 40 weekdays. During this period, the animals' electrocardiogram (ECG), deep body temperature (Tdb), and body weight (BW) were registered, and concentrations of PM, CO, NO2, as well as air temperature and relative humidity (RH) were measured. Data analysis included random effects models with lagged covariate methods. Results: CO was significantly associated with declines in heart rate (HR) and heart rate variability (HRV), PM was significantly associated with declines in HRV and BW, and NO2 was significantly associated with declines in HR. Some significant associations occurred in the same day (PM and HRV, PM and BW, CO and HR), whereas others were delayed by 1 to 3 days (CO and HR, CO and HRV, NO 2 and HR, PM and HRV). Discussion and conclusion: Finding significant declines in heart function in aged mice associated with the combined effects of air pollutants at ambient concentrations and at different time-lags is of great importance to public health. These results further implicate the potential short term and delayed effects of air pollution on HR alterations.
AB - Context: Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. Objective: Determine the association at different time-lags between the complex mixture of ambient concentrations of PM, carbon monoxide (CO), and nitrogen dioxide (NO2), and markers of cardiac function in a model of aged mice. Materials and methods: AKR/J inbred mice were exposed to ambient air, 6h daily for 40 weekdays. During this period, the animals' electrocardiogram (ECG), deep body temperature (Tdb), and body weight (BW) were registered, and concentrations of PM, CO, NO2, as well as air temperature and relative humidity (RH) were measured. Data analysis included random effects models with lagged covariate methods. Results: CO was significantly associated with declines in heart rate (HR) and heart rate variability (HRV), PM was significantly associated with declines in HRV and BW, and NO2 was significantly associated with declines in HR. Some significant associations occurred in the same day (PM and HRV, PM and BW, CO and HR), whereas others were delayed by 1 to 3 days (CO and HR, CO and HRV, NO 2 and HR, PM and HRV). Discussion and conclusion: Finding significant declines in heart function in aged mice associated with the combined effects of air pollutants at ambient concentrations and at different time-lags is of great importance to public health. These results further implicate the potential short term and delayed effects of air pollution on HR alterations.
KW - Aging
KW - Gaseous pollutants
KW - Heart rate variability
KW - Longitudinal data analysis
KW - Particulate matter
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U2 - 10.3109/08958370903349365
DO - 10.3109/08958370903349365
M3 - Article
C2 - 20105060
AN - SCOPUS:77149142241
SN - 0895-8378
VL - 22
SP - 330
EP - 339
JO - Inhalation Toxicology
JF - Inhalation Toxicology
IS - 4
ER -