Amantadine: evaluation of reinforcing properties and effect on cocaine self-injection in baboons

Christine A. Sannerud, Roland R Griffiths

Research output: Contribution to journalArticle

Abstract

The ability of amantadine to maintain self-injection behavior and to alter self-administration of cocaine was examined in baboons using a standard intravenous cocaine self-injection procedure. Responding was maintained under a FR 80- or 160-response schedule of intravenous cocaine delivery (0.32 mg/kg per injection). Each drug injection was followed by a 3-h timeout allowing a maximum of 8 injections/day. Vehicle or amantadine doses were substituted for cocaine for a period of 15 or more days. Evaluation of a wide range of amantadine doses (0.32-32 mg/kg per injection) showed that this compound did not maintain self-administration behavior above vehicle control levels. In another experiment using the cocaine self-injection baseline, amantadine (10 or 32 mg/kg per day) was administered via a chronic intravenous infusion. Cocaine self-injection behavior was maintained and re-initiated during chronic amantadine exposure, suggesting that the reinforcing efficacy of cocaine was not modified by chronic amantadine administration.

Original languageEnglish (US)
Pages (from-to)195-202
Number of pages8
JournalDrug and Alcohol Dependence
Volume21
Issue number3
DOIs
StatePublished - 1988

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Keywords

  • amantadine
  • baboon
  • cocaine
  • self-administration

ASJC Scopus subject areas

  • Medicine(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

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