Alzheimer's therapy: an approach to novel muscarinic ligands based upon the naturally occurring alkaloid himbacine.

Alan P. Kozikowski, Abdul H. Fauq, Jacqueline H. Miller, Michael McKinney

Research output: Contribution to journalArticlepeer-review

Abstract

The naturally occurring alkaloid himbacine has been found to be a potent muscarinic antagonist that displays selectivity for M2 or M4 receptors. Using himbacine as a lead compound we have begun to explore its structure-activity profile in order to arrive at an analogue for possible use in cholinergic pharmacotherapy.

Original languageEnglish (US)
Pages (from-to)797-802
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume2
Issue number8
DOIs
StatePublished - Aug 1992

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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