Alzheimer's therapy: an approach to novel muscarinic ligands based upon the naturally occurring alkaloid himbacine.

Alan P. Kozikowski; Abdul H. Fauq; Jacqueline H. Miller; Michael McKinney

doi:10.1016/S0960-894X(00)80534-X

Alzheimer's therapy: an approach to novel muscarinic ligands based upon the naturally occurring alkaloid himbacine.

Alan P. Kozikowski, Abdul H. Fauq, Jacqueline H. Miller, Michael McKinney

School of Medicine

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The naturally occurring alkaloid himbacine has been found to be a potent muscarinic antagonist that displays selectivity for M2 or M4 receptors. Using himbacine as a lead compound we have begun to explore its structure-activity profile in order to arrive at an analogue for possible use in cholinergic pharmacotherapy.

Original language	English (US)
Pages (from-to)	797-802
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	2
Issue number	8
DOIs	https://doi.org/10.1016/S0960-894X(00)80534-X
State	Published - Aug 1992

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)80534-X

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abstract = "The naturally occurring alkaloid himbacine has been found to be a potent muscarinic antagonist that displays selectivity for M2 or M4 receptors. Using himbacine as a lead compound we have begun to explore its structure-activity profile in order to arrive at an analogue for possible use in cholinergic pharmacotherapy.",

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AU - McKinney, Michael

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AB - The naturally occurring alkaloid himbacine has been found to be a potent muscarinic antagonist that displays selectivity for M2 or M4 receptors. Using himbacine as a lead compound we have begun to explore its structure-activity profile in order to arrive at an analogue for possible use in cholinergic pharmacotherapy.

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Alzheimer's therapy: an approach to novel muscarinic ligands based upon the naturally occurring alkaloid himbacine.

Abstract

ASJC Scopus subject areas

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