Abstract
The morbid risk of Alzheimer's disease was studied in first-degree relatives of 50 patients who met contemporary clinical research diagnostic criteria and 45 matched controls. Relatives of patients showed a 46% cumulative incidence of probable Alzheimer's disease by 86 years of age. The risk, which was four times the control value, is consistent with other recent reports using similar, modern methods. Although not conclusive, the data suggest the operation of a relatively common, dominant autosomal gene for Alzheimer's disease, the expression of which is delayed until late old age but is largely complete by 90 years of age.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 405-408 |
| Number of pages | 4 |
| Journal | Archives of General Psychiatry |
| Volume | 44 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Psychiatry and Mental health
Cite this
Alzheimer's Disease : Morbid Risk Among First-Degree Relatives Approximates 50% by 90 Years of Age. / Mohs, Richard C.; Breitner, John C.S.; Silverman, Jeremy M.; Davis, Kenneth L.
In: Archives of General Psychiatry, Vol. 44, No. 5, 1987, p. 405-408.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alzheimer's Disease
T2 - Morbid Risk Among First-Degree Relatives Approximates 50% by 90 Years of Age
AU - Mohs, Richard C.
AU - Breitner, John C.S.
AU - Silverman, Jeremy M.
AU - Davis, Kenneth L.
PY - 1987
Y1 - 1987
N2 - The morbid risk of Alzheimer's disease was studied in first-degree relatives of 50 patients who met contemporary clinical research diagnostic criteria and 45 matched controls. Relatives of patients showed a 46% cumulative incidence of probable Alzheimer's disease by 86 years of age. The risk, which was four times the control value, is consistent with other recent reports using similar, modern methods. Although not conclusive, the data suggest the operation of a relatively common, dominant autosomal gene for Alzheimer's disease, the expression of which is delayed until late old age but is largely complete by 90 years of age.
AB - The morbid risk of Alzheimer's disease was studied in first-degree relatives of 50 patients who met contemporary clinical research diagnostic criteria and 45 matched controls. Relatives of patients showed a 46% cumulative incidence of probable Alzheimer's disease by 86 years of age. The risk, which was four times the control value, is consistent with other recent reports using similar, modern methods. Although not conclusive, the data suggest the operation of a relatively common, dominant autosomal gene for Alzheimer's disease, the expression of which is delayed until late old age but is largely complete by 90 years of age.
UR - http://www.scopus.com/inward/record.url?scp=0023184672&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023184672&partnerID=8YFLogxK
U2 - 10.1001/archpsyc.1987.01800170019003
DO - 10.1001/archpsyc.1987.01800170019003
M3 - Article
C2 - 3579492
AN - SCOPUS:0023184672
VL - 44
SP - 405
EP - 408
JO - JAMA Psychiatry
JF - JAMA Psychiatry
SN - 2168-622X
IS - 5
ER -