Alzheimer's disease: Low levels of peptide a-amidation activity in brain and CSF

G. S. Wand; C. May; V. May; P. J. Whitehouse; S. I. Rapoport; B. A. Eipper

doi:10.1212/wnl.37.6.1057

Alzheimer's disease: Low levels of peptide a-amidation activity in brain and CSF

G. S. Wand, C. May, V. May, P. J. Whitehouse, S. I. Rapoport, B. A. Eipper

School of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Carboxyl terminal a-amidation confers biologic activity to many neuropeptides. Levels of a-amidating activity, peptidyl-glycine α-amidating monooxygenase (PAM), were reduced in the CSF of patients with dementia of the Alzheimer type (DAT) compared with healthy, age-matched controls. Repeat lumbar puncture data revealed a decline in CSF PAM activity of approximately 16% per year in DAT patients. Of the cerebral cortical regions examined, only the temporal pole showed reduced PAM activity in patients with Alzheimer's disease (AD) compared with controls. These studies may indicate selective dysfunction of neurons which normally synthesize biologically active, a-amidated peptides in the CNS of AD patients.

Original language	English (US)
Pages (from-to)	1057-1061
Number of pages	5
Journal	Neurology
Volume	37
Issue number	6
DOIs	https://doi.org/10.1212/wnl.37.6.1057
State	Published - Jun 1987

ASJC Scopus subject areas

Clinical Neurology

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abstract = "Carboxyl terminal a-amidation confers biologic activity to many neuropeptides. Levels of a-amidating activity, peptidyl-glycine α-amidating monooxygenase (PAM), were reduced in the CSF of patients with dementia of the Alzheimer type (DAT) compared with healthy, age-matched controls. Repeat lumbar puncture data revealed a decline in CSF PAM activity of approximately 16% per year in DAT patients. Of the cerebral cortical regions examined, only the temporal pole showed reduced PAM activity in patients with Alzheimer's disease (AD) compared with controls. These studies may indicate selective dysfunction of neurons which normally synthesize biologically active, a-amidated peptides in the CNS of AD patients.",

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AU - May, C.

AU - May, V.

AU - Whitehouse, P. J.

AU - Rapoport, S. I.

AU - Eipper, B. A.

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Alzheimer's disease: Low levels of peptide a-amidation activity in brain and CSF

Abstract

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