TY - JOUR
T1 - Alzheimer's disease and related dementias
T2 - Selective involvement of specific neuronal systems
AU - Whitehouse, P. J.
AU - Struble, R. G.
AU - Hedreen, J. C.
AU - Clark, A. W.
AU - Price, D. L.
PY - 1985
Y1 - 1985
N2 - The degenerative disorders of the CNS are of considerable historical, social, economical, and neurobiological significance. This review has provided a framework for investigations of the disordered brain-behavior relationships occurring in these particular conditions. For heuristic purposes, our discussion had focused on the cholinergic and noradrenergic cortical projecting systems in AD and related dementias. However, changes in neurons of these systems are only one feature of the pathology of AD and related dementias and, as such, this review represents a simplification of a more complicated pathophysiology. While we have focused on selective examples, we feel that the approach defined in this review is applicable to a variety of neuronal populations in a variety of degenerative diseases of the CNS.
AB - The degenerative disorders of the CNS are of considerable historical, social, economical, and neurobiological significance. This review has provided a framework for investigations of the disordered brain-behavior relationships occurring in these particular conditions. For heuristic purposes, our discussion had focused on the cholinergic and noradrenergic cortical projecting systems in AD and related dementias. However, changes in neurons of these systems are only one feature of the pathology of AD and related dementias and, as such, this review represents a simplification of a more complicated pathophysiology. While we have focused on selective examples, we feel that the approach defined in this review is applicable to a variety of neuronal populations in a variety of degenerative diseases of the CNS.
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M3 - Review article
C2 - 2876845
AN - SCOPUS:0021803045
SN - 0742-941X
VL - 1
SP - 319
EP - 339
JO - CRC Critical Reviews in Clinical Neurobiology
JF - CRC Critical Reviews in Clinical Neurobiology
IS - 4
ER -