Alzheimer's disease: β-amyloid precursor protein expression in plaques varies among cytoarchitectonic areas of the medial temporal lobe

Greer M. Murphy, Erin Murphy, Barry D. Greenberg, Barbara Cordell, Lawrence F. Eng, William G. Ellis, Lysia S. Forno, Shahriar M. Salamat, Patricia A. Gonzalez-DeWhitt, David E. Lowery, Jared R. Tinklenberg

Research output: Contribution to journalArticlepeer-review

Abstract

The anatomic distributions of β-amyloid peptide (βAP) and β-amyloid precursor protein (βAPP) in the medial temporal lobe were examined with immunocytochemistry in Alzheimer's disease. βAP-containing plaques were found most frequently in the cortical and basal regions of the amygdala, and in the hippocampal CA1, subiculum, and dentate molecular layer. βAPP expression in plaques was found in a similar distribution, with some, but not all βAP plaques also showing βAPP. In the cortical and basal amygdala, some cases showed βAPP in the centers of plaques, whereas in the hippocampus, all cases displayed βAPP mainly in plaque neurites. The lateral regions of the amygdala contained mainly diffuse βAP plaques which had little β APP. These findings suggest that although βAPP expression and βAP deposition generally colocalize, processing of βAPP may vary among closely interconnected anatomic regions.

Original languageEnglish (US)
Pages (from-to)100-104
Number of pages5
JournalNeuroscience Letters
Volume131
Issue number1
DOIs
StatePublished - Sep 30 1991
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amygdala
  • Hippocampus
  • Immunocytochemistry
  • Neuritic plaque
  • β-Amyloid precursor protein

ASJC Scopus subject areas

  • Neuroscience(all)

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