Alzheimer's disease: β-amyloid precursor protein expression in plaques varies among cytoarchitectonic areas of the medial temporal lobe

Greer M. Murphy; Erin Murphy; Barry D. Greenberg; Barbara Cordell; Lawrence F. Eng; William G. Ellis; Lysia S. Forno; Shahriar M. Salamat; Patricia A. Gonzalez-DeWhitt; David E. Lowery; Jared R. Tinklenberg

doi:10.1016/0304-3940(91)90346-U

Alzheimer's disease: β-amyloid precursor protein expression in plaques varies among cytoarchitectonic areas of the medial temporal lobe

Greer M. Murphy, Erin Murphy, Barry D. Greenberg, Barbara Cordell, Lawrence F. Eng, William G. Ellis, Lysia S. Forno, Shahriar M. Salamat, Patricia A. Gonzalez-DeWhitt, David E. Lowery, Jared R. Tinklenberg

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The anatomic distributions of β-amyloid peptide (βAP) and β-amyloid precursor protein (βAPP) in the medial temporal lobe were examined with immunocytochemistry in Alzheimer's disease. βAP-containing plaques were found most frequently in the cortical and basal regions of the amygdala, and in the hippocampal CA1, subiculum, and dentate molecular layer. βAPP expression in plaques was found in a similar distribution, with some, but not all βAP plaques also showing βAPP. In the cortical and basal amygdala, some cases showed βAPP in the centers of plaques, whereas in the hippocampus, all cases displayed βAPP mainly in plaque neurites. The lateral regions of the amygdala contained mainly diffuse βAP plaques which had little β APP. These findings suggest that although βAPP expression and βAP deposition generally colocalize, processing of βAPP may vary among closely interconnected anatomic regions.

Original language	English (US)
Pages (from-to)	100-104
Number of pages	5
Journal	Neuroscience Letters
Volume	131
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(91)90346-U
State	Published - Sep 30 1991
Externally published	Yes

Keywords

Alzheimer's disease
Amygdala
Hippocampus
Immunocytochemistry
Neuritic plaque
β-Amyloid precursor protein

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(91)90346-U

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Murphy, G. M., Murphy, E., Greenberg, B. D., Cordell, B., Eng, L. F., Ellis, W. G., Forno, L. S., Salamat, S. M., Gonzalez-DeWhitt, P. A., Lowery, D. E., & Tinklenberg, J. R. (1991). Alzheimer's disease: β-amyloid precursor protein expression in plaques varies among cytoarchitectonic areas of the medial temporal lobe. Neuroscience Letters, 131(1), 100-104. https://doi.org/10.1016/0304-3940(91)90346-U

Murphy, GM, Murphy, E, Greenberg, BD, Cordell, B, Eng, LF, Ellis, WG, Forno, LS, Salamat, SM, Gonzalez-DeWhitt, PA, Lowery, DE & Tinklenberg, JR 1991, 'Alzheimer's disease: β-amyloid precursor protein expression in plaques varies among cytoarchitectonic areas of the medial temporal lobe', Neuroscience Letters, vol. 131, no. 1, pp. 100-104. https://doi.org/10.1016/0304-3940(91)90346-U

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title = "Alzheimer's disease: β-amyloid precursor protein expression in plaques varies among cytoarchitectonic areas of the medial temporal lobe",

abstract = "The anatomic distributions of β-amyloid peptide (βAP) and β-amyloid precursor protein (βAPP) in the medial temporal lobe were examined with immunocytochemistry in Alzheimer's disease. βAP-containing plaques were found most frequently in the cortical and basal regions of the amygdala, and in the hippocampal CA1, subiculum, and dentate molecular layer. βAPP expression in plaques was found in a similar distribution, with some, but not all βAP plaques also showing βAPP. In the cortical and basal amygdala, some cases showed βAPP in the centers of plaques, whereas in the hippocampus, all cases displayed βAPP mainly in plaque neurites. The lateral regions of the amygdala contained mainly diffuse βAP plaques which had little β APP. These findings suggest that although βAPP expression and βAP deposition generally colocalize, processing of βAPP may vary among closely interconnected anatomic regions.",

keywords = "Alzheimer's disease, Amygdala, Hippocampus, Immunocytochemistry, Neuritic plaque, β-Amyloid precursor protein",

author = "Murphy, {Greer M.} and Erin Murphy and Greenberg, {Barry D.} and Barbara Cordell and Eng, {Lawrence F.} and Ellis, {William G.} and Forno, {Lysia S.} and Salamat, {Shahriar M.} and Gonzalez-DeWhitt, {Patricia A.} and Lowery, {David E.} and Tinklenberg, {Jared R.}",

note = "Funding Information: Dr. D. Selkoe kindly provided the PHF antiserum. Supported by VA Medical Research, the NIMH, and the State of California.",

year = "1991",

month = sep,

day = "30",

doi = "10.1016/0304-3940(91)90346-U",

language = "English (US)",

volume = "131",

pages = "100--104",

journal = "Neuroscience Letters",

issn = "0304-3940",

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TY - JOUR

T1 - Alzheimer's disease

T2 - β-amyloid precursor protein expression in plaques varies among cytoarchitectonic areas of the medial temporal lobe

AU - Murphy, Greer M.

AU - Murphy, Erin

AU - Greenberg, Barry D.

AU - Cordell, Barbara

AU - Eng, Lawrence F.

AU - Ellis, William G.

AU - Forno, Lysia S.

AU - Salamat, Shahriar M.

AU - Gonzalez-DeWhitt, Patricia A.

AU - Lowery, David E.

AU - Tinklenberg, Jared R.

N1 - Funding Information: Dr. D. Selkoe kindly provided the PHF antiserum. Supported by VA Medical Research, the NIMH, and the State of California.

PY - 1991/9/30

Y1 - 1991/9/30

N2 - The anatomic distributions of β-amyloid peptide (βAP) and β-amyloid precursor protein (βAPP) in the medial temporal lobe were examined with immunocytochemistry in Alzheimer's disease. βAP-containing plaques were found most frequently in the cortical and basal regions of the amygdala, and in the hippocampal CA1, subiculum, and dentate molecular layer. βAPP expression in plaques was found in a similar distribution, with some, but not all βAP plaques also showing βAPP. In the cortical and basal amygdala, some cases showed βAPP in the centers of plaques, whereas in the hippocampus, all cases displayed βAPP mainly in plaque neurites. The lateral regions of the amygdala contained mainly diffuse βAP plaques which had little β APP. These findings suggest that although βAPP expression and βAP deposition generally colocalize, processing of βAPP may vary among closely interconnected anatomic regions.

AB - The anatomic distributions of β-amyloid peptide (βAP) and β-amyloid precursor protein (βAPP) in the medial temporal lobe were examined with immunocytochemistry in Alzheimer's disease. βAP-containing plaques were found most frequently in the cortical and basal regions of the amygdala, and in the hippocampal CA1, subiculum, and dentate molecular layer. βAPP expression in plaques was found in a similar distribution, with some, but not all βAP plaques also showing βAPP. In the cortical and basal amygdala, some cases showed βAPP in the centers of plaques, whereas in the hippocampus, all cases displayed βAPP mainly in plaque neurites. The lateral regions of the amygdala contained mainly diffuse βAP plaques which had little β APP. These findings suggest that although βAPP expression and βAP deposition generally colocalize, processing of βAPP may vary among closely interconnected anatomic regions.

KW - Alzheimer's disease

KW - Amygdala

KW - Hippocampus

KW - Immunocytochemistry

KW - Neuritic plaque

KW - β-Amyloid precursor protein

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Alzheimer's disease: β-amyloid precursor protein expression in plaques varies among cytoarchitectonic areas of the medial temporal lobe

Abstract

Keywords

ASJC Scopus subject areas

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