TY - JOUR
T1 - Alzheimer-type neuropathology and clinical symptoms of dementia in mentally retarded people without Down syndrome
AU - Barcikowska, M.
AU - Silverman, W.
AU - Zigman, W.
AU - Kozlowski, P. B.
AU - Kujawa, M.
AU - Rudelli, R.
AU - Wisniewski, H. M.
PY - 1989
Y1 - 1989
N2 - Postmortem morphometric analyses of Bielschowsky stained sections from brains of 70 mentally retarded people without Down syndrome, age 65 and over when they died, indicated Alzheimer-type neuropathology in 22 cases (31%) and a majority with at least presence of some Alzheimer-type lesions. Based upon information abstracted from clinical histories, however, old-age-associated dementia proved to be difficult to judge reliably. Nevertheless, for otherwise healthy individuals (n = 25), loss of motor skills, development of problem behaviors, and a 10-point drop in IQ appeared to be likely indicators of Alzheimer's disease. Prevalence estimates of Alzheimer-type neuropathology among nonretarded people and the present sample appear comparable, and projections must be made to address the special needs of this rapidly growing population of retarded people.
AB - Postmortem morphometric analyses of Bielschowsky stained sections from brains of 70 mentally retarded people without Down syndrome, age 65 and over when they died, indicated Alzheimer-type neuropathology in 22 cases (31%) and a majority with at least presence of some Alzheimer-type lesions. Based upon information abstracted from clinical histories, however, old-age-associated dementia proved to be difficult to judge reliably. Nevertheless, for otherwise healthy individuals (n = 25), loss of motor skills, development of problem behaviors, and a 10-point drop in IQ appeared to be likely indicators of Alzheimer's disease. Prevalence estimates of Alzheimer-type neuropathology among nonretarded people and the present sample appear comparable, and projections must be made to address the special needs of this rapidly growing population of retarded people.
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M3 - Article
C2 - 2706124
AN - SCOPUS:0024505780
VL - 93
SP - 551
EP - 557
JO - American Journal on Mental Retardation
JF - American Journal on Mental Retardation
SN - 1944-7515
IS - 5
ER -