Alzheimer peptides perturb lipid-regulating enzymes

Mark P. Mattson, Roy G. Cutler, Dong Gyu Jo

Research output: Contribution to journalArticle

Abstract

An increase in the size of the amyloid β-peptide (Aβ versus Aβ40) may be a key factor in the pathogenesis of Alzheimer's disease. By altering the activities of enzymes involved in the metabolism of cholesterol and sphingomyelin, an increase in the Aβ42:Aβ40 ratio may cause dysfunction and death of neurons.

Original languageEnglish (US)
Pages (from-to)1045-1047
Number of pages3
JournalNature Cell Biology
Volume7
Issue number11
DOIs
StatePublished - Nov 2005
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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    Mattson, M. P., Cutler, R. G., & Jo, D. G. (2005). Alzheimer peptides perturb lipid-regulating enzymes. Nature Cell Biology, 7(11), 1045-1047. https://doi.org/10.1038/ncb1105-1045