Alzheimer peptides perturb lipid-regulating enzymes

Mark P. Mattson; Roy G. Cutler; Dong Gyu Jo

doi:10.1038/ncb1105-1045

Alzheimer peptides perturb lipid-regulating enzymes

Mark P. Mattson, Roy G. Cutler, Dong Gyu Jo

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

An increase in the size of the amyloid β-peptide (Aβ versus Aβ40) may be a key factor in the pathogenesis of Alzheimer's disease. By altering the activities of enzymes involved in the metabolism of cholesterol and sphingomyelin, an increase in the Aβ42:Aβ40 ratio may cause dysfunction and death of neurons.

Original language	English (US)
Pages (from-to)	1045-1047
Number of pages	3
Journal	Nature Cell Biology
Volume	7
Issue number	11
DOIs	https://doi.org/10.1038/ncb1105-1045
State	Published - Nov 2005
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

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abstract = "An increase in the size of the amyloid β-peptide (Aβ versus Aβ40) may be a key factor in the pathogenesis of Alzheimer's disease. By altering the activities of enzymes involved in the metabolism of cholesterol and sphingomyelin, an increase in the Aβ42:Aβ40 ratio may cause dysfunction and death of neurons.",

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Alzheimer peptides perturb lipid-regulating enzymes

Abstract

ASJC Scopus subject areas

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