Alzheimer diseases

Alena V. Savonenko; Philip C. Wong; Tong Li

doi:10.1016/B978-0-323-85654-6.00022-8

Alzheimer diseases

Alena V. Savonenko, Philip C. Wong, Tong Li

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Over the past several years, significant advances have been made in many areas of Alzheimer's disease (AD) research. Here, we review several key topics that influence our understanding of pathogenic mechanisms and lead to the identification of novel therapeutic strategies. These include the diagnostic spectrum of MCI and AD, genetic risk alleles associated with late-onset AD, structures of gamma-secretase and tau, imaging and fluid biomarkers, the role of microglia and neuroinflammation, and novel animal models of AD.

Original language	English (US)
Title of host publication	Neurobiology of Brain Disorders
Subtitle of host publication	Biological Basis of Neurological and Psychiatric Disorders, Second Edition
Publisher	Elsevier
Pages	313-336
Number of pages	24
ISBN (Electronic)	9780323856546
ISBN (Print)	9780323898256
DOIs	https://doi.org/10.1016/B978-0-323-85654-6.00022-8
State	Published - Jan 1 2022

Keywords

Amyloid precursor protein (APP)
Aβ plaques
Neurofibrillary tangles (NFT)
Tau
β-site APP cleaving enzyme-1 (BACE 1)
γ-Secretase

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/B978-0-323-85654-6.00022-8

Cite this

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title = "Alzheimer diseases",

abstract = "Over the past several years, significant advances have been made in many areas of Alzheimer's disease (AD) research. Here, we review several key topics that influence our understanding of pathogenic mechanisms and lead to the identification of novel therapeutic strategies. These include the diagnostic spectrum of MCI and AD, genetic risk alleles associated with late-onset AD, structures of gamma-secretase and tau, imaging and fluid biomarkers, the role of microglia and neuroinflammation, and novel animal models of AD.",

keywords = "Amyloid precursor protein (APP), Aβ plaques, Neurofibrillary tangles (NFT), Tau, β-site APP cleaving enzyme-1 (BACE 1), γ-Secretase",

author = "Savonenko, {Alena V.} and Wong, {Philip C.} and Tong Li",

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AU - Savonenko, Alena V.

AU - Wong, Philip C.

AU - Li, Tong

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N2 - Over the past several years, significant advances have been made in many areas of Alzheimer's disease (AD) research. Here, we review several key topics that influence our understanding of pathogenic mechanisms and lead to the identification of novel therapeutic strategies. These include the diagnostic spectrum of MCI and AD, genetic risk alleles associated with late-onset AD, structures of gamma-secretase and tau, imaging and fluid biomarkers, the role of microglia and neuroinflammation, and novel animal models of AD.

AB - Over the past several years, significant advances have been made in many areas of Alzheimer's disease (AD) research. Here, we review several key topics that influence our understanding of pathogenic mechanisms and lead to the identification of novel therapeutic strategies. These include the diagnostic spectrum of MCI and AD, genetic risk alleles associated with late-onset AD, structures of gamma-secretase and tau, imaging and fluid biomarkers, the role of microglia and neuroinflammation, and novel animal models of AD.

KW - Amyloid precursor protein (APP)

KW - Aβ plaques

KW - Neurofibrillary tangles (NFT)

KW - Tau

KW - β-site APP cleaving enzyme-1 (BACE 1)

KW - γ-Secretase

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DO - 10.1016/B978-0-323-85654-6.00022-8

M3 - Chapter

AN - SCOPUS:85141289799

SN - 9780323898256

SP - 313

EP - 336

BT - Neurobiology of Brain Disorders

PB - Elsevier

ER -

Alzheimer diseases

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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