Alzheimer disease: Measuring loss of cerebral gray matter with MR imaging

Henry Rusinek, Mony J. De Leon, Ajax E. George, Leonidas A. Stylopoulos, Ramesh Chandra, Gwenn Smith, Thomas Rand, Manuel Mourino, Henryk Kowalski

Research output: Contribution to journalArticlepeer-review

192 Scopus citations


The distributions of the cerebral gray matter, the white matter, and the intracranial cerebrospinal fluid (CSF) were measured in 14 patients with Alzheimer disease (AD) and in 14 healthy control subjects. The measurements, derived from two specifically designed magnetic resonance inversion-recovery sequences, compensate for partial signal averaging. The percentage of the gray matter in the brains of AD patients (44.9% ± 4.4) was significantly lower than in control subjects (50.2% ± 3.2). The most significant reduction (P < .001) occurred in the temporal lobes (13.8%) and a central region (12.8%); the reduction in frontal lobe (11.2%) and occipital lobe (9.2%) was also statistically significant (P < .01). There was an increase in the CSF volume in the temporal, occipital, and frontal regions; no region showed a significant difference in the white matter content. The findings of diffuse changes and temporal lobe involvement in AD are consistent with pathologic observations of cortical cell loss.

Original languageEnglish (US)
Pages (from-to)109-114
Number of pages6
Issue number1
StatePublished - Jan 1991
Externally publishedYes


  • Brain, MR studies, 10.1214
  • Brain, atrophy, 10.83
  • Dementia, 10.83
  • Magnetic resonance (MR), image processing
  • Magnetic resonance (MR), tissue characterization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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