Alveolar macrophage dysfunction associated with viral pneumonitis.

G. J. Jakab, G. A. Warr, P. L. Sannes

Research output: Contribution to journalArticle

Abstract

Viral infections are known to predispose to bacterial infections of the lung. Studies on the virus-induced suppression of pulmonary bactericidal mechanisms have identified the defect with abnormalities in the alveolar macrophage phagocytic system. In the investigation presented herein, we have dissected some of the subcomponents of the phagocytic process and found virus-induced defects in phagocytic ingestion, phagosome-lysosome fusion, and intracellular killing.

Original languageEnglish (US)
Pages (from-to)81-90
Number of pages10
JournalAdvances in Experimental Medicine and Biology
Volume121 B
StatePublished - 1979
Externally publishedYes

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Alveolar Macrophages
Viruses
Pneumonia
Phagosomes
Lung
Defects
Virus Diseases
Lysosomes
Bacterial Infections
Fusion reactions
Eating

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Alveolar macrophage dysfunction associated with viral pneumonitis. / Jakab, G. J.; Warr, G. A.; Sannes, P. L.

In: Advances in Experimental Medicine and Biology, Vol. 121 B, 1979, p. 81-90.

Research output: Contribution to journalArticle

Jakab, G. J. ; Warr, G. A. ; Sannes, P. L. / Alveolar macrophage dysfunction associated with viral pneumonitis. In: Advances in Experimental Medicine and Biology. 1979 ; Vol. 121 B. pp. 81-90.
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