Alternative splicing of GTBP in normal human tissues

Hiromi O. Shiwaku, Shigeru Wakatsuki, Yuriko Mori, Shinichi Fukushige, Akira Horii

Research output: Contribution to journalArticlepeer-review

Abstract

GTBP is one of the functional homologues of the bacterial mismatch repair gene mutS, whose product forms a heterodimer with hMSH2 to bind to the mismatched region of double-stranded DNA. We determined the expression of the GTBP gene and found that two forms of the transcripts were ubiquitously expressed in normal human tissues. These transcripts, termed GTBP-N and GTBP-ALT, were generated by the alternative splicing machinery. These two transcripts share 3172 bp from the translation initiation codon that codes for 1057 amino acids. GTBP-ALT lacked a region that codes for a highly conserved region between GTBP-N, hMSH2, and hMSH3 in their C-termini.

Original languageEnglish (US)
Pages (from-to)359-362
Number of pages4
JournalDNA Research
Volume4
Issue number5
DOIs
StatePublished - 1997

Keywords

  • Alternative splicing
  • DNA mismatch repair
  • GTBP

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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