Alternative splicing in 5′-untranslational region of STK-15 gene, encoding centrosome associated kinase, in breast cancer cell lines

Sei One Shin, Kwan Ho Lee, Jung Hye Kim, Suk Hwan Baek, Jong Wook Park, Edward W. Gabrielson, Taeg Kyu Kwon

Research output: Contribution to journalArticle

Abstract

Centrosomes maintain genomic stability by establishing the bipolar spindles during cell division and execute accurate segregation of chromosomes during mitosis. In this study, we have demonstrated that there are three forms of STK-15 gene in breast cancer cell lines. Alternative splice positions are located in 5′-untranslated region of STK15 gene. The results of in vitro translation experiments revealed that the alternative splicing in the 5′-untranslated region of STK15 had no effect on protein translation. The differential expression patterns of these alternatively spliced STK15 in breast cell lines and primary tumors therefore suggest that STK15 gene transcription may be differentially regulated or stabilized in these cells.

Original languageEnglish (US)
Pages (from-to)193-196
Number of pages4
JournalExperimental and Molecular Medicine
Volume32
Issue number4
StatePublished - Dec 31 2000

Keywords

  • Alternative splicing
  • Breast cancer
  • Cell cycle
  • Centrosome
  • STK15
  • Serine/threonine kinase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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