Alternative Human Cell Models for Neuropsychiatric Research: Induced Neuronal Cells, Olfactory Epithelium, and Related Resources

Brian Lo, Daniel Chang, Shinichi Kano

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Understanding the altered function of the human brain is central to neuropsychiatric research. Although studies in genetics, brain imaging, postmortem brains, and animal models have greatly expanded our knowledge about neuropsychiatric disorders, much less is known about the changes at the molecular and cellular levels in live brain cells. It is crucial to fill this gap to further advance our understanding of neuropsychiatric disorders and to move forward to the development of novel therapeutic strategies. Recently, induced pluripotent stem cells have been highlighted as key tools to study live brain cells from patients with brain disorders. There have been, however, alternative approaches to study live brain cells using cell fate conversion (direct reprogramming) or reprogramming-free methods. In this chapter, we will summarize these alternative human cell models and discuss their utilities and potentials in neuropsychiatric research.

Original languageEnglish (US)
Title of host publicationHandbook of Behavioral Neuroscience
PublisherElsevier B.V.
Pages407-422
Number of pages16
Volume23
DOIs
StatePublished - 2016

Publication series

NameHandbook of Behavioral Neuroscience
Volume23
ISSN (Print)15697339

Keywords

  • Cell fate conversion
  • Direct reprogramming
  • Induced neuronal (iN) cells
  • Induced neuronal stem (iNS) cells
  • Induced pluripotent stem (iPS) cells
  • Neuropsychiatric disorders
  • Olfactory epithelium
  • Postmortem brains

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Behavioral Neuroscience

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