Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4

Hyosang Lee, Tohko Iida, Atsuko Mizuno, Makoto Suzuki, Michael J. Caterina

Research output: Contribution to journalArticlepeer-review

209 Scopus citations


Transient receptor potential vanilloid 4 (TRPV4), a cation channel responsive to hypotonicity, can also be activated by warm temperatures. Moreover, TRPV4-/- mice reportedly exhibit deficits in inflammation-induced thermal hyperalgesia. However, it is unknown whether TRPV4 or related transient receptor potential channels account for warmth perception under injury-free conditions. We therefore investigated the contribution of TRPV4 to thermosensation and thermoregulation in vivo. On a thermal gradient, TRPV4-/- mice selected warmer floor temperatures than wild-type littermates. In addition, whereas wild-type mice failed to discriminate between floor temperatures of 30 and 34°C, TRPV4-/- mice exhibited a strong preference for 34°C. TRPV4-/- mice also exhibited prolonged withdrawal latencies during acute tail heating. TRPV4-/- and wild-type mice exhibited similar changes in behavior on a thermal gradient after paw inflammation. Circadian body temperature fluctuations and thermoregulation in a warm environment were also indistinguishable between genotypes. These results demonstrate that TRPV4 is required for normal thermal responsiveness in vivo.

Original languageEnglish (US)
Pages (from-to)1304-1310
Number of pages7
JournalJournal of Neuroscience
Issue number5
StatePublished - Feb 2 2005


  • Heat
  • Pain
  • TRPV4
  • Temperature
  • Thermosensation
  • Warm

ASJC Scopus subject areas

  • Neuroscience(all)


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