Altered task-related modulation of long-range connectivity in children with autism

Ajay S. Pillai, Danielle McAuliffe, Balaji M. Lakshmanan, Stewart H Mostofsky, Nathan E Crone, Joshua Benjamin Ewen

Research output: Contribution to journalArticle

Abstract

Functional connectivity differences between children with autism spectrum disorder (ASD) and typically developing children have been described in multiple datasets. However, few studies examine the task-related changes in connectivity in disorder-relevant behavioral paradigms. In this paper, we examined the task-related changes in functional connectivity using EEG and a movement-based paradigm that has behavioral relevance to ASD. Resting-state studies motivated our hypothesis that children with ASD would show a decreased magnitude of functional connectivity during the performance of a motor-control task. Contrary to our initial hypothesis, however, we observed that task-related modulation of functional connectivity in children with ASD was in the direction opposite to that of TDs. The task-related connectivity changes were correlated with clinical symptom scores. Our results suggest that children with ASD may have differences in cortical segregation/integration during the performance of a task, and that part of the differences in connectivity modulation may serve as a compensatory mechanism. Autism Res 2018, 11: 245–257.

Original languageEnglish (US)
Pages (from-to)245-257
Number of pages13
JournalAutism Research
Volume11
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Autistic Disorder
Task Performance and Analysis
Electroencephalography
Autism Spectrum Disorder

Keywords

  • autism
  • connectivity
  • dyspraxia
  • EEG
  • functional connectivity
  • task-related

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Genetics(clinical)

Cite this

Altered task-related modulation of long-range connectivity in children with autism. / Pillai, Ajay S.; McAuliffe, Danielle; Lakshmanan, Balaji M.; Mostofsky, Stewart H; Crone, Nathan E; Ewen, Joshua Benjamin.

In: Autism Research, Vol. 11, No. 2, 01.02.2018, p. 245-257.

Research output: Contribution to journalArticle

Pillai, Ajay S. ; McAuliffe, Danielle ; Lakshmanan, Balaji M. ; Mostofsky, Stewart H ; Crone, Nathan E ; Ewen, Joshua Benjamin. / Altered task-related modulation of long-range connectivity in children with autism. In: Autism Research. 2018 ; Vol. 11, No. 2. pp. 245-257.
@article{5f9b9e3c48644764afcb57bc1c034547,
title = "Altered task-related modulation of long-range connectivity in children with autism",
abstract = "Functional connectivity differences between children with autism spectrum disorder (ASD) and typically developing children have been described in multiple datasets. However, few studies examine the task-related changes in connectivity in disorder-relevant behavioral paradigms. In this paper, we examined the task-related changes in functional connectivity using EEG and a movement-based paradigm that has behavioral relevance to ASD. Resting-state studies motivated our hypothesis that children with ASD would show a decreased magnitude of functional connectivity during the performance of a motor-control task. Contrary to our initial hypothesis, however, we observed that task-related modulation of functional connectivity in children with ASD was in the direction opposite to that of TDs. The task-related connectivity changes were correlated with clinical symptom scores. Our results suggest that children with ASD may have differences in cortical segregation/integration during the performance of a task, and that part of the differences in connectivity modulation may serve as a compensatory mechanism. Autism Res 2018, 11: 245–257.",
keywords = "autism, connectivity, dyspraxia, EEG, functional connectivity, task-related",
author = "Pillai, {Ajay S.} and Danielle McAuliffe and Lakshmanan, {Balaji M.} and Mostofsky, {Stewart H} and Crone, {Nathan E} and Ewen, {Joshua Benjamin}",
year = "2018",
month = "2",
day = "1",
doi = "10.1002/aur.1858",
language = "English (US)",
volume = "11",
pages = "245--257",
journal = "Autism Research",
issn = "1939-3806",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Altered task-related modulation of long-range connectivity in children with autism

AU - Pillai, Ajay S.

AU - McAuliffe, Danielle

AU - Lakshmanan, Balaji M.

AU - Mostofsky, Stewart H

AU - Crone, Nathan E

AU - Ewen, Joshua Benjamin

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Functional connectivity differences between children with autism spectrum disorder (ASD) and typically developing children have been described in multiple datasets. However, few studies examine the task-related changes in connectivity in disorder-relevant behavioral paradigms. In this paper, we examined the task-related changes in functional connectivity using EEG and a movement-based paradigm that has behavioral relevance to ASD. Resting-state studies motivated our hypothesis that children with ASD would show a decreased magnitude of functional connectivity during the performance of a motor-control task. Contrary to our initial hypothesis, however, we observed that task-related modulation of functional connectivity in children with ASD was in the direction opposite to that of TDs. The task-related connectivity changes were correlated with clinical symptom scores. Our results suggest that children with ASD may have differences in cortical segregation/integration during the performance of a task, and that part of the differences in connectivity modulation may serve as a compensatory mechanism. Autism Res 2018, 11: 245–257.

AB - Functional connectivity differences between children with autism spectrum disorder (ASD) and typically developing children have been described in multiple datasets. However, few studies examine the task-related changes in connectivity in disorder-relevant behavioral paradigms. In this paper, we examined the task-related changes in functional connectivity using EEG and a movement-based paradigm that has behavioral relevance to ASD. Resting-state studies motivated our hypothesis that children with ASD would show a decreased magnitude of functional connectivity during the performance of a motor-control task. Contrary to our initial hypothesis, however, we observed that task-related modulation of functional connectivity in children with ASD was in the direction opposite to that of TDs. The task-related connectivity changes were correlated with clinical symptom scores. Our results suggest that children with ASD may have differences in cortical segregation/integration during the performance of a task, and that part of the differences in connectivity modulation may serve as a compensatory mechanism. Autism Res 2018, 11: 245–257.

KW - autism

KW - connectivity

KW - dyspraxia

KW - EEG

KW - functional connectivity

KW - task-related

UR - http://www.scopus.com/inward/record.url?scp=85042359405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042359405&partnerID=8YFLogxK

U2 - 10.1002/aur.1858

DO - 10.1002/aur.1858

M3 - Article

VL - 11

SP - 245

EP - 257

JO - Autism Research

JF - Autism Research

SN - 1939-3806

IS - 2

ER -