Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart

Hongwei Jin, Robert D. Nass, Paul J. Joudrey, Alexander R. Lyon, Elie R. Chemaly, Kleopatra Rapti, Fadi G. Akar

Research output: Contribution to journalArticlepeer-review

Abstract

Chronically elevated levels of oxidative stress resulting from increased production and/or impaired scavenging of reactive oxygen species are a hallmark of mitochondrial dysfunction in left ventricular hypertrophy. Recently, oscillations of the mitochondrial membrane potential (Δψm) were mechanistically linked to changes in cellular excitability under conditions of acute oxidative stress produced by laser-induced photooxidation of cardiac myocytes in vitro. Here, we investigate the spatiotemporal dynamics of Δψm within the intact heart during ischemla-reperfuslon injury. We hypothesize that altered metabolic properties in left ventricular hypertrophy modulate Δψm spatiotemporal properties and arrhythmia propensity.

Original languageEnglish (US)
Pages (from-to)2063-2071
Number of pages9
JournalBiophysical journal
Volume98
Issue number10
DOIs
StatePublished - May 19 2010

ASJC Scopus subject areas

  • Biophysics

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