Altered sleep patterns in patients with non-functional GHRH receptor

Francielle T. Oliveira, Roberto Salvatori, José Marcondes, Larissa B. Macena, Alecia A. Oliveira-Santos, Augusto C.N. Faro, Viviane C. Campos, Carla R.P. Oliveira, Ursula M.M. Costa, Manuel H. Aguiar-Oliveira

Research output: Contribution to journalArticle

Abstract

Objectives: GH-releasing hormone (GHRH) exerts hypnotic actions increasing the non-rapid eye movement (NREM) sleep. Conversely, GH stimulates the REM sleep. GH deficiency (GHD) often leads to sleep problems, daytime fatigue and reduced quality of life (QoL). GHD may be due to lack of hypothalamic GHRH or destruction of somatotroph cells. We have described a cohort with isolated GHD (IGHD) due to GHRH resistance caused by a homozygous null mutation (c.57 + 1G > A) in the GHRH receptor gene. They have normal QoL and no obvious complaints of chronic tiredness. The aim of this study was to determine the sleep quality in these subjects. Methods: A cross-sectional study was carried out in 21 adult IGHD subjects, and 21 age-And gender-matched controls. Objective sleep assessment included polygraphic records of the awake, stages NREM [N1 (drowsiness), N2 and N3 (already sleeping)] and REM (R). Subjective evaluation included the Pittsburgh Sleep Quality Index, the Insomnia Severity Index and the Epworth Sleepiness Scale. Results: IGHD subjects showed a reduction in sleep efficiency (P = 0.007), total sleep time (P = 0.028), duration of N2 and R in minutes (P = 0.026 and P = 0.046 respectively), but had increased duration and percentage of N1 stage (P = 0.029 and P = 0.022 respectively), wake (P = 0.007) and wake-Time after sleep onset (P = 0.017). There was no difference in N3 or in sleep quality questionnaire scores. Conclusion: Patients with IGHD due to GHRH resistance exhibit objective reduction in the sleep quality, with changes in NREM and REM sleep, with no detectable subjective consequences. GHRH resistance seems to have a preponderant role over GHD in the sleep quality of these subjects.

Original languageEnglish (US)
Pages (from-to)51-57
Number of pages7
JournalEuropean Journal of Endocrinology
Volume177
Issue number1
DOIs
StatePublished - Jul 1 2017

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Sleep
Hormones
Eye Movements
REM Sleep
Quality of Life
Pituitary Dwarfism
Somatotrophs
Pituitary Hormone-Releasing Hormones
Sleep Stages
Sleep Initiation and Maintenance Disorders
Hypnotics and Sedatives
Fatigue
Cross-Sectional Studies
Mutation
Genes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Oliveira, F. T., Salvatori, R., Marcondes, J., Macena, L. B., Oliveira-Santos, A. A., Faro, A. C. N., ... Aguiar-Oliveira, M. H. (2017). Altered sleep patterns in patients with non-functional GHRH receptor. European Journal of Endocrinology, 177(1), 51-57. https://doi.org/10.1530/EJE-17-0145

Altered sleep patterns in patients with non-functional GHRH receptor. / Oliveira, Francielle T.; Salvatori, Roberto; Marcondes, José; Macena, Larissa B.; Oliveira-Santos, Alecia A.; Faro, Augusto C.N.; Campos, Viviane C.; Oliveira, Carla R.P.; Costa, Ursula M.M.; Aguiar-Oliveira, Manuel H.

In: European Journal of Endocrinology, Vol. 177, No. 1, 01.07.2017, p. 51-57.

Research output: Contribution to journalArticle

Oliveira, FT, Salvatori, R, Marcondes, J, Macena, LB, Oliveira-Santos, AA, Faro, ACN, Campos, VC, Oliveira, CRP, Costa, UMM & Aguiar-Oliveira, MH 2017, 'Altered sleep patterns in patients with non-functional GHRH receptor', European Journal of Endocrinology, vol. 177, no. 1, pp. 51-57. https://doi.org/10.1530/EJE-17-0145
Oliveira FT, Salvatori R, Marcondes J, Macena LB, Oliveira-Santos AA, Faro ACN et al. Altered sleep patterns in patients with non-functional GHRH receptor. European Journal of Endocrinology. 2017 Jul 1;177(1):51-57. https://doi.org/10.1530/EJE-17-0145
Oliveira, Francielle T. ; Salvatori, Roberto ; Marcondes, José ; Macena, Larissa B. ; Oliveira-Santos, Alecia A. ; Faro, Augusto C.N. ; Campos, Viviane C. ; Oliveira, Carla R.P. ; Costa, Ursula M.M. ; Aguiar-Oliveira, Manuel H. / Altered sleep patterns in patients with non-functional GHRH receptor. In: European Journal of Endocrinology. 2017 ; Vol. 177, No. 1. pp. 51-57.
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abstract = "Objectives: GH-releasing hormone (GHRH) exerts hypnotic actions increasing the non-rapid eye movement (NREM) sleep. Conversely, GH stimulates the REM sleep. GH deficiency (GHD) often leads to sleep problems, daytime fatigue and reduced quality of life (QoL). GHD may be due to lack of hypothalamic GHRH or destruction of somatotroph cells. We have described a cohort with isolated GHD (IGHD) due to GHRH resistance caused by a homozygous null mutation (c.57 + 1G > A) in the GHRH receptor gene. They have normal QoL and no obvious complaints of chronic tiredness. The aim of this study was to determine the sleep quality in these subjects. Methods: A cross-sectional study was carried out in 21 adult IGHD subjects, and 21 age-And gender-matched controls. Objective sleep assessment included polygraphic records of the awake, stages NREM [N1 (drowsiness), N2 and N3 (already sleeping)] and REM (R). Subjective evaluation included the Pittsburgh Sleep Quality Index, the Insomnia Severity Index and the Epworth Sleepiness Scale. Results: IGHD subjects showed a reduction in sleep efficiency (P = 0.007), total sleep time (P = 0.028), duration of N2 and R in minutes (P = 0.026 and P = 0.046 respectively), but had increased duration and percentage of N1 stage (P = 0.029 and P = 0.022 respectively), wake (P = 0.007) and wake-Time after sleep onset (P = 0.017). There was no difference in N3 or in sleep quality questionnaire scores. Conclusion: Patients with IGHD due to GHRH resistance exhibit objective reduction in the sleep quality, with changes in NREM and REM sleep, with no detectable subjective consequences. GHRH resistance seems to have a preponderant role over GHD in the sleep quality of these subjects.",
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AU - Salvatori, Roberto

AU - Marcondes, José

AU - Macena, Larissa B.

AU - Oliveira-Santos, Alecia A.

AU - Faro, Augusto C.N.

AU - Campos, Viviane C.

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