Abstract
The healing rate of full-thickness skin lesions is slower in senescent female rats (22-23 months) than in their young adult (5-6 months) counterparts. Fifty percent wound closure times were 9.46 ± 0.31 and 6.45 ± 0.40 days, respectively (P < 0.001). Ovariectomy significantly slows the healing process in the mature group but not in the senescent animals. Treatment of ovariectomized rats with low-dose estradiol (0.3 μg/kg body wt) restores the healing rate to nearly normal in mature rats and accelerates the healing rate relative to sham-operated controls in senescent rats. Thus, decreased healing rates in senescent female rats may be due in part to reduced estrogenic potentiation of healing.
Original language | English (US) |
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Pages (from-to) | 17-23 |
Number of pages | 7 |
Journal | Proceedings of the Society for Experimental Biology and Medicine |
Volume | 166 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1981 |
Externally published | Yes |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology