Altered Ovarian Regulation of Wound Healing during Aging

George S. Roth, S. Mitchell Harman, Stanford I. Lamberg

Research output: Contribution to journalArticle


The healing rate of full-thickness skin lesions is slower in senescent female rats (22-23 months) than in their young adult (5-6 months) counterparts. Fifty percent wound closure times were 9.46 ± 0.31 and 6.45 ± 0.40 days, respectively (P < 0.001). Ovariectomy significantly slows the healing process in the mature group but not in the senescent animals. Treatment of ovariectomized rats with low-dose estradiol (0.3 μg/kg body wt) restores the healing rate to nearly normal in mature rats and accelerates the healing rate relative to sham-operated controls in senescent rats. Thus, decreased healing rates in senescent female rats may be due in part to reduced estrogenic potentiation of healing.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
StatePublished - Jan 1981

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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