The healing rate of full-thickness skin lesions is slower in senescent female rats (22-23 months) than in their young adult (5-6 months) counterparts. Fifty percent wound closure times were 9.46 ± 0.31 and 6.45 ± 0.40 days, respectively (P < 0.001). Ovariectomy significantly slows the healing process in the mature group but not in the senescent animals. Treatment of ovariectomized rats with low-dose estradiol (0.3 μg/kg body wt) restores the healing rate to nearly normal in mature rats and accelerates the healing rate relative to sham-operated controls in senescent rats. Thus, decreased healing rates in senescent female rats may be due in part to reduced estrogenic potentiation of healing.
|Original language||English (US)|
|Number of pages||7|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Jan 1981|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)