Altered neurochemical markers in Rett's syndrome

G. L. Wenk, S. Naidu, M. F. Casanova, C. A. Kitt, H. Moser

Research output: Contribution to journalArticle

Abstract

Rett's syndrome (RS) is a neurologic disorder associated with severe mental deficiency and neurologic manifestations of cortical and extrapyramidal origin. The present report is a preliminary postmortem brain study that compares the levels of endogenous biogenic amines and selected neurotransmitter receptors in five cases with RS and six normal controls of similar age. The level of choline acetyltransferase activity was reduced in several cortical and subcortical regions. Endogenous levels of dopamine in the superior frontal and superior temporal gyri, occipital cortex, and putamen were reduced. The changes in specific neurotransmitter markers, particularly those associated with the basal ganglia and cortex, may underlie the progressive deterioration in motor and cognitive function characteristic of this progressive disorder.

Original languageEnglish (US)
Pages (from-to)1753-1756
Number of pages4
JournalNeurology
Volume41
Issue number11
DOIs
StatePublished - Nov 1991

ASJC Scopus subject areas

  • Clinical Neurology

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    Wenk, G. L., Naidu, S., Casanova, M. F., Kitt, C. A., & Moser, H. (1991). Altered neurochemical markers in Rett's syndrome. Neurology, 41(11), 1753-1756. https://doi.org/10.1212/wnl.41.11.1753