Altered MHC class I expression in dorsolateral prefrontal cortex of nonsmoker patients with schizophrenia

Shin ichi Kano, Evaristus Nwulia, Minae Niwa, Yian Chen, Akira Sawa, Nicola Cascella

Research output: Contribution to journalArticlepeer-review

Abstract

Schizophrenia (SZ) is a psychiatric disease with plausible neurodevelopmental etiology. Although genetic studies show significant association of immune molecules loci such as major histocompatibility complex (MHC) class I with SZ, it is not clear whether these immune molecules are involved in the pathology observed in SZ brains. MHC class I and the classical pathway components of complement system (C1q and C3) have been shown to regulate brain neuronal maturation and function. We have examined the expression of MHC class I and complement protein C3 in two frontal cortical regions of postmortem brains of SZ patients. Since cigarette smoking may modulate MHC class I protein expression and a higher rate of smoking is observed in SZ patients, we studied the expression of MHC class I and C3 in relation to the presence of smoking. We found that MHC class I protein expression is reduced in the dorsolateral prefrontal cortex (DLPFC) but not in the orbitofrontal cortex (OFC) of nonsmoker SZ patients. We did not observe SZ-associated changes in C3 mRNA expression. Our exploratory research suggests a potential involvement of MHC class I in SZ and implies that smoking might modulate its expression.

Original languageEnglish (US)
Pages (from-to)289-293
Number of pages5
JournalNeuroscience Research
Volume71
Issue number3
DOIs
StatePublished - Nov 1 2011

Keywords

  • Complement proteins
  • Dorsolateral prefrontal cortex (DLPFC)
  • Immune molecule
  • MHC class I
  • Orbitofrontal cortex (OFC)
  • Schizophrenia (SZ)

ASJC Scopus subject areas

  • Neuroscience(all)

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