Altered MHC class I expression in dorsolateral prefrontal cortex of nonsmoker patients with schizophrenia

Shinichi Kano, Evaristus Nwulia, Minae Niwa, Yian Chen, Akira Sawa, Nicola Cascella

Research output: Contribution to journalArticle

Abstract

Schizophrenia (SZ) is a psychiatric disease with plausible neurodevelopmental etiology. Although genetic studies show significant association of immune molecules loci such as major histocompatibility complex (MHC) class I with SZ, it is not clear whether these immune molecules are involved in the pathology observed in SZ brains. MHC class I and the classical pathway components of complement system (C1q and C3) have been shown to regulate brain neuronal maturation and function. We have examined the expression of MHC class I and complement protein C3 in two frontal cortical regions of postmortem brains of SZ patients. Since cigarette smoking may modulate MHC class I protein expression and a higher rate of smoking is observed in SZ patients, we studied the expression of MHC class I and C3 in relation to the presence of smoking. We found that MHC class I protein expression is reduced in the dorsolateral prefrontal cortex (DLPFC) but not in the orbitofrontal cortex (OFC) of nonsmoker SZ patients. We did not observe SZ-associated changes in C3 mRNA expression. Our exploratory research suggests a potential involvement of MHC class I in SZ and implies that smoking might modulate its expression.

Original languageEnglish (US)
Pages (from-to)289-293
Number of pages5
JournalNeuroscience Research
Volume71
Issue number3
DOIs
StatePublished - Nov 2011

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Prefrontal Cortex
Major Histocompatibility Complex
Schizophrenia
Smoking
Complement C3
Brain
Complement C1q
Psychiatry
Complement System Proteins
Proteins
Pathology
Messenger RNA
Research

Keywords

  • Complement proteins
  • Dorsolateral prefrontal cortex (DLPFC)
  • Immune molecule
  • MHC class I
  • Orbitofrontal cortex (OFC)
  • Schizophrenia (SZ)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Altered MHC class I expression in dorsolateral prefrontal cortex of nonsmoker patients with schizophrenia. / Kano, Shinichi; Nwulia, Evaristus; Niwa, Minae; Chen, Yian; Sawa, Akira; Cascella, Nicola.

In: Neuroscience Research, Vol. 71, No. 3, 11.2011, p. 289-293.

Research output: Contribution to journalArticle

Kano, Shinichi ; Nwulia, Evaristus ; Niwa, Minae ; Chen, Yian ; Sawa, Akira ; Cascella, Nicola. / Altered MHC class I expression in dorsolateral prefrontal cortex of nonsmoker patients with schizophrenia. In: Neuroscience Research. 2011 ; Vol. 71, No. 3. pp. 289-293.
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