Altered Levels of Toll-Like Receptors in Circulating Extracellular Vesicles in Multiple Sclerosis

Pavan Bhargava, Carlos Nogueras-Ortiz, Sahil Chawla, Rikke Bæk, Malene Møller Jørgensen, Dimitrios Kapogiannis

Research output: Contribution to journalArticlepeer-review

Abstract

Extracellular vesicles (EVs) are involved in inter-cellular communication and their cargo may provide prognostic/diagnostic biomarkers. To discover EV-associated biomarkers for Multiple Sclerosis (MS), we used an immune marker array to identify surface proteins on circulating EVs that differ between MS patients and controls (n = 3 each). We identified toll-like receptor-3 (TLR3) as a potential target for further validation. We utilized prospectively collected serum from relapsing-remitting MS patients (n = 18) and controls (n = 16) and confirmed lower concentration of TLR3 and higher concentration of mechanistically related TLR4 in MS EVs compared to controls. Future studies may further evaluate the utility of EV-associated TLRs as MS biomarkers and uncover their mechanistic significance.

Original languageEnglish (US)
JournalCells
Volume8
Issue number9
DOIs
StatePublished - Sep 10 2019

Keywords

  • TLR3
  • TLR4
  • extracellular vesicles
  • innate immunity
  • multiple sclerosis

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Altered Levels of Toll-Like Receptors in Circulating Extracellular Vesicles in Multiple Sclerosis'. Together they form a unique fingerprint.

Cite this