Altered follicular development in clomiphene citrate versus human menopausal gonadotropin-stimulated cycles for in vitro fertilization

A. M. Dlugi, N. Laufer, W. Botero-Ruiz, A. H. DeCherney, M. L. Polan, F. P. Haseltine, H. C. Mezer, H. R. Behrman

Research output: Contribution to journalArticle

Abstract

The pattern of periovulatory and luteal phase serum estradiol (E2) and progesterone (P) as well as follicular fluid (FF) E2, P, androgen, gonadotropin, and prolactin concentrations of eight women undergoing clomiphene citrate (CC)/human chorionic gonadotropin (hCG) stimulation and eight women undergoing human menopausal gonadotropin (hMG)/hCG stimulation of follicular development for the purpose of in vitro fertilization were compared. Ovulation was induced with either a 5-day course of CC (100 mg/day beginning on day 5 of the cycle) or an individualized hMG regimen, and laparoscopy was performed 36 hours after hCG administration. The length of the luteal phase was significantly longer (P < 0.05) in the CC-treated group as compared with the hMG-treated group. The pattern of serum E2 levels differed significantly (P < 0.01) in that E2 levels were lower in the early and midluteal phase in CC-stimulated cycles; in addition, a delayed second E2 peak was observed in the late luteal phase in these women. Serum P levels, however, were lower in the hMG-stimulated group. Analysis of FF hormone concentrations revealed significantly (P < 0.05) higher concentrations of E2 and androsterone in the FF of hMG-treated patients. It is concluded that follicular development in CC-stimulated cycles differs markedly from that in hMG-stimulated cycles. These differences may reflect either an altered follicular maturational process or may represent a direct inhibitory effect of CC on follicular steroidogenesis.

Original languageEnglish (US)
Pages (from-to)40-47
Number of pages8
JournalFertility and sterility
Volume43
Issue number1
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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    Dlugi, A. M., Laufer, N., Botero-Ruiz, W., DeCherney, A. H., Polan, M. L., Haseltine, F. P., Mezer, H. C., & Behrman, H. R. (1985). Altered follicular development in clomiphene citrate versus human menopausal gonadotropin-stimulated cycles for in vitro fertilization. Fertility and sterility, 43(1), 40-47. https://doi.org/10.1016/S0015-0282(16)48315-9