Altered Excitation-inhibition Balance in the Brain of Patients with Diabetic Neuropathy

Myria Petrou, Rodica Pop-Busui, Bradley R. Foerster, Richard Anthony Edward Edden, Brian C. Callaghan, Steve E. Harte, Richard E. Harris, Daniel J. Clauw, Eva L. Feldman

Research output: Contribution to journalArticle

Abstract

Rationale and Objectives: To assess differences in excitatory (glutamate/glutamine or Glx) and inhibitory (γ-Aminobutyric acid or GABA) neurotransmitter levels using MR spectroscopy in pain processing regions of the brain in patients diabetic neuropathy (DN) and positive sensory symptoms and age-matched healthy control (HC) subjects. Materials and Methods: Seven diabetic patients (5 males, 2 females, mean age = 57.0 ± 8.5 years) with confirmed DN and positive sensory symptoms and 7 age and sex matched HC subjects (mean age = 57.7 ± 3.2 years) underwent 3 Tesla MR spectroscopy. Glx and GABA levels were quantified in the right anterior and posterior insula, anterior cingulate cortex and right thalamus. Results: Mean Glx levels were significantly higher and mean GABA levels were significantly lower within the posterior insula in the DN patients compared to HC (P = 0.005 and 0.012 respectively). Conclusions: This pilot data demonstrates an excitatory/inhibitory neurotransmitter imbalance in the brain of in patients with DN and positive sensory symptoms compared to pain free HC subjects.

Original languageEnglish (US)
Pages (from-to)607-612
Number of pages6
JournalAcademic Radiology
Volume19
Issue number5
DOIs
StatePublished - May 2012

Fingerprint

Diabetic Neuropathies
gamma-Aminobutyric Acid
Healthy Volunteers
Brain
Neurotransmitter Agents
Magnetic Resonance Spectroscopy
Aminobutyrates
Gyrus Cinguli
Glutamine
Thalamus
Glutamic Acid
Pain
Inhibition (Psychology)

Keywords

  • Diabetes
  • MR spectroscopy
  • Neuropathy
  • Pain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Petrou, M., Pop-Busui, R., Foerster, B. R., Edden, R. A. E., Callaghan, B. C., Harte, S. E., ... Feldman, E. L. (2012). Altered Excitation-inhibition Balance in the Brain of Patients with Diabetic Neuropathy. Academic Radiology, 19(5), 607-612. https://doi.org/10.1016/j.acra.2012.02.004

Altered Excitation-inhibition Balance in the Brain of Patients with Diabetic Neuropathy. / Petrou, Myria; Pop-Busui, Rodica; Foerster, Bradley R.; Edden, Richard Anthony Edward; Callaghan, Brian C.; Harte, Steve E.; Harris, Richard E.; Clauw, Daniel J.; Feldman, Eva L.

In: Academic Radiology, Vol. 19, No. 5, 05.2012, p. 607-612.

Research output: Contribution to journalArticle

Petrou, M, Pop-Busui, R, Foerster, BR, Edden, RAE, Callaghan, BC, Harte, SE, Harris, RE, Clauw, DJ & Feldman, EL 2012, 'Altered Excitation-inhibition Balance in the Brain of Patients with Diabetic Neuropathy', Academic Radiology, vol. 19, no. 5, pp. 607-612. https://doi.org/10.1016/j.acra.2012.02.004
Petrou, Myria ; Pop-Busui, Rodica ; Foerster, Bradley R. ; Edden, Richard Anthony Edward ; Callaghan, Brian C. ; Harte, Steve E. ; Harris, Richard E. ; Clauw, Daniel J. ; Feldman, Eva L. / Altered Excitation-inhibition Balance in the Brain of Patients with Diabetic Neuropathy. In: Academic Radiology. 2012 ; Vol. 19, No. 5. pp. 607-612.
@article{64a4d54b4a734d7dabaf1e39eac6d46e,
title = "Altered Excitation-inhibition Balance in the Brain of Patients with Diabetic Neuropathy",
abstract = "Rationale and Objectives: To assess differences in excitatory (glutamate/glutamine or Glx) and inhibitory (γ-Aminobutyric acid or GABA) neurotransmitter levels using MR spectroscopy in pain processing regions of the brain in patients diabetic neuropathy (DN) and positive sensory symptoms and age-matched healthy control (HC) subjects. Materials and Methods: Seven diabetic patients (5 males, 2 females, mean age = 57.0 ± 8.5 years) with confirmed DN and positive sensory symptoms and 7 age and sex matched HC subjects (mean age = 57.7 ± 3.2 years) underwent 3 Tesla MR spectroscopy. Glx and GABA levels were quantified in the right anterior and posterior insula, anterior cingulate cortex and right thalamus. Results: Mean Glx levels were significantly higher and mean GABA levels were significantly lower within the posterior insula in the DN patients compared to HC (P = 0.005 and 0.012 respectively). Conclusions: This pilot data demonstrates an excitatory/inhibitory neurotransmitter imbalance in the brain of in patients with DN and positive sensory symptoms compared to pain free HC subjects.",
keywords = "Diabetes, MR spectroscopy, Neuropathy, Pain",
author = "Myria Petrou and Rodica Pop-Busui and Foerster, {Bradley R.} and Edden, {Richard Anthony Edward} and Callaghan, {Brian C.} and Harte, {Steve E.} and Harris, {Richard E.} and Clauw, {Daniel J.} and Feldman, {Eva L.}",
year = "2012",
month = "5",
doi = "10.1016/j.acra.2012.02.004",
language = "English (US)",
volume = "19",
pages = "607--612",
journal = "Academic Radiology",
issn = "1076-6332",
publisher = "Elsevier USA",
number = "5",

}

TY - JOUR

T1 - Altered Excitation-inhibition Balance in the Brain of Patients with Diabetic Neuropathy

AU - Petrou, Myria

AU - Pop-Busui, Rodica

AU - Foerster, Bradley R.

AU - Edden, Richard Anthony Edward

AU - Callaghan, Brian C.

AU - Harte, Steve E.

AU - Harris, Richard E.

AU - Clauw, Daniel J.

AU - Feldman, Eva L.

PY - 2012/5

Y1 - 2012/5

N2 - Rationale and Objectives: To assess differences in excitatory (glutamate/glutamine or Glx) and inhibitory (γ-Aminobutyric acid or GABA) neurotransmitter levels using MR spectroscopy in pain processing regions of the brain in patients diabetic neuropathy (DN) and positive sensory symptoms and age-matched healthy control (HC) subjects. Materials and Methods: Seven diabetic patients (5 males, 2 females, mean age = 57.0 ± 8.5 years) with confirmed DN and positive sensory symptoms and 7 age and sex matched HC subjects (mean age = 57.7 ± 3.2 years) underwent 3 Tesla MR spectroscopy. Glx and GABA levels were quantified in the right anterior and posterior insula, anterior cingulate cortex and right thalamus. Results: Mean Glx levels were significantly higher and mean GABA levels were significantly lower within the posterior insula in the DN patients compared to HC (P = 0.005 and 0.012 respectively). Conclusions: This pilot data demonstrates an excitatory/inhibitory neurotransmitter imbalance in the brain of in patients with DN and positive sensory symptoms compared to pain free HC subjects.

AB - Rationale and Objectives: To assess differences in excitatory (glutamate/glutamine or Glx) and inhibitory (γ-Aminobutyric acid or GABA) neurotransmitter levels using MR spectroscopy in pain processing regions of the brain in patients diabetic neuropathy (DN) and positive sensory symptoms and age-matched healthy control (HC) subjects. Materials and Methods: Seven diabetic patients (5 males, 2 females, mean age = 57.0 ± 8.5 years) with confirmed DN and positive sensory symptoms and 7 age and sex matched HC subjects (mean age = 57.7 ± 3.2 years) underwent 3 Tesla MR spectroscopy. Glx and GABA levels were quantified in the right anterior and posterior insula, anterior cingulate cortex and right thalamus. Results: Mean Glx levels were significantly higher and mean GABA levels were significantly lower within the posterior insula in the DN patients compared to HC (P = 0.005 and 0.012 respectively). Conclusions: This pilot data demonstrates an excitatory/inhibitory neurotransmitter imbalance in the brain of in patients with DN and positive sensory symptoms compared to pain free HC subjects.

KW - Diabetes

KW - MR spectroscopy

KW - Neuropathy

KW - Pain

UR - http://www.scopus.com/inward/record.url?scp=84858991693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858991693&partnerID=8YFLogxK

U2 - 10.1016/j.acra.2012.02.004

DO - 10.1016/j.acra.2012.02.004

M3 - Article

VL - 19

SP - 607

EP - 612

JO - Academic Radiology

JF - Academic Radiology

SN - 1076-6332

IS - 5

ER -