Altered Excitation-inhibition Balance in the Brain of Patients with Diabetic Neuropathy

Myria Petrou; Rodica Pop-Busui; Bradley R. Foerster; Richard A. Edden; Brian C. Callaghan; Steve E. Harte; Richard E. Harris; Daniel J. Clauw; Eva L. Feldman

doi:10.1016/j.acra.2012.02.004

Altered Excitation-inhibition Balance in the Brain of Patients with Diabetic Neuropathy

Myria Petrou, Rodica Pop-Busui, Bradley R. Foerster, Richard A. Edden, Brian C. Callaghan, Steve E. Harte, Richard E. Harris, Daniel J. Clauw, Eva L. Feldman

School of Medicine

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Rationale and Objectives: To assess differences in excitatory (glutamate/glutamine or Glx) and inhibitory (γ-Aminobutyric acid or GABA) neurotransmitter levels using MR spectroscopy in pain processing regions of the brain in patients diabetic neuropathy (DN) and positive sensory symptoms and age-matched healthy control (HC) subjects. Materials and Methods: Seven diabetic patients (5 males, 2 females, mean age = 57.0 ± 8.5 years) with confirmed DN and positive sensory symptoms and 7 age and sex matched HC subjects (mean age = 57.7 ± 3.2 years) underwent 3 Tesla MR spectroscopy. Glx and GABA levels were quantified in the right anterior and posterior insula, anterior cingulate cortex and right thalamus. Results: Mean Glx levels were significantly higher and mean GABA levels were significantly lower within the posterior insula in the DN patients compared to HC (P = 0.005 and 0.012 respectively). Conclusions: This pilot data demonstrates an excitatory/inhibitory neurotransmitter imbalance in the brain of in patients with DN and positive sensory symptoms compared to pain free HC subjects.

Original language	English (US)
Pages (from-to)	607-612
Number of pages	6
Journal	Academic radiology
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/j.acra.2012.02.004
State	Published - May 2012

Keywords

Diabetes
MR spectroscopy
Neuropathy
Pain

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1016/j.acra.2012.02.004

Cite this

@article{64a4d54b4a734d7dabaf1e39eac6d46e,

title = "Altered Excitation-inhibition Balance in the Brain of Patients with Diabetic Neuropathy",

abstract = "Rationale and Objectives: To assess differences in excitatory (glutamate/glutamine or Glx) and inhibitory (γ-Aminobutyric acid or GABA) neurotransmitter levels using MR spectroscopy in pain processing regions of the brain in patients diabetic neuropathy (DN) and positive sensory symptoms and age-matched healthy control (HC) subjects. Materials and Methods: Seven diabetic patients (5 males, 2 females, mean age = 57.0 ± 8.5 years) with confirmed DN and positive sensory symptoms and 7 age and sex matched HC subjects (mean age = 57.7 ± 3.2 years) underwent 3 Tesla MR spectroscopy. Glx and GABA levels were quantified in the right anterior and posterior insula, anterior cingulate cortex and right thalamus. Results: Mean Glx levels were significantly higher and mean GABA levels were significantly lower within the posterior insula in the DN patients compared to HC (P = 0.005 and 0.012 respectively). Conclusions: This pilot data demonstrates an excitatory/inhibitory neurotransmitter imbalance in the brain of in patients with DN and positive sensory symptoms compared to pain free HC subjects.",

keywords = "Diabetes, MR spectroscopy, Neuropathy, Pain",

author = "Myria Petrou and Rodica Pop-Busui and Foerster, {Bradley R.} and Edden, {Richard A.} and Callaghan, {Brian C.} and Harte, {Steve E.} and Harris, {Richard E.} and Clauw, {Daniel J.} and Feldman, {Eva L.}",

note = "Funding Information: Supported by the Program in Neurology Research and Discovery at the University of Michigan, the Juvenile Diabetes Research Foundation (JDRF) and the Radiological Society of North America (RSNA). ",

year = "2012",

month = may,

doi = "10.1016/j.acra.2012.02.004",

language = "English (US)",

volume = "19",

pages = "607--612",

journal = "Academic radiology",

issn = "1076-6332",

publisher = "Elsevier USA",

number = "5",

}

TY - JOUR

T1 - Altered Excitation-inhibition Balance in the Brain of Patients with Diabetic Neuropathy

AU - Petrou, Myria

AU - Pop-Busui, Rodica

AU - Foerster, Bradley R.

AU - Edden, Richard A.

AU - Callaghan, Brian C.

AU - Harte, Steve E.

AU - Harris, Richard E.

AU - Clauw, Daniel J.

AU - Feldman, Eva L.

N1 - Funding Information: Supported by the Program in Neurology Research and Discovery at the University of Michigan, the Juvenile Diabetes Research Foundation (JDRF) and the Radiological Society of North America (RSNA).

PY - 2012/5

Y1 - 2012/5

N2 - Rationale and Objectives: To assess differences in excitatory (glutamate/glutamine or Glx) and inhibitory (γ-Aminobutyric acid or GABA) neurotransmitter levels using MR spectroscopy in pain processing regions of the brain in patients diabetic neuropathy (DN) and positive sensory symptoms and age-matched healthy control (HC) subjects. Materials and Methods: Seven diabetic patients (5 males, 2 females, mean age = 57.0 ± 8.5 years) with confirmed DN and positive sensory symptoms and 7 age and sex matched HC subjects (mean age = 57.7 ± 3.2 years) underwent 3 Tesla MR spectroscopy. Glx and GABA levels were quantified in the right anterior and posterior insula, anterior cingulate cortex and right thalamus. Results: Mean Glx levels were significantly higher and mean GABA levels were significantly lower within the posterior insula in the DN patients compared to HC (P = 0.005 and 0.012 respectively). Conclusions: This pilot data demonstrates an excitatory/inhibitory neurotransmitter imbalance in the brain of in patients with DN and positive sensory symptoms compared to pain free HC subjects.

AB - Rationale and Objectives: To assess differences in excitatory (glutamate/glutamine or Glx) and inhibitory (γ-Aminobutyric acid or GABA) neurotransmitter levels using MR spectroscopy in pain processing regions of the brain in patients diabetic neuropathy (DN) and positive sensory symptoms and age-matched healthy control (HC) subjects. Materials and Methods: Seven diabetic patients (5 males, 2 females, mean age = 57.0 ± 8.5 years) with confirmed DN and positive sensory symptoms and 7 age and sex matched HC subjects (mean age = 57.7 ± 3.2 years) underwent 3 Tesla MR spectroscopy. Glx and GABA levels were quantified in the right anterior and posterior insula, anterior cingulate cortex and right thalamus. Results: Mean Glx levels were significantly higher and mean GABA levels were significantly lower within the posterior insula in the DN patients compared to HC (P = 0.005 and 0.012 respectively). Conclusions: This pilot data demonstrates an excitatory/inhibitory neurotransmitter imbalance in the brain of in patients with DN and positive sensory symptoms compared to pain free HC subjects.

KW - Diabetes

KW - MR spectroscopy

KW - Neuropathy

KW - Pain

UR - http://www.scopus.com/inward/record.url?scp=84858991693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858991693&partnerID=8YFLogxK

U2 - 10.1016/j.acra.2012.02.004

DO - 10.1016/j.acra.2012.02.004

M3 - Article

C2 - 22463961

AN - SCOPUS:84858991693

SN - 1076-6332

VL - 19

SP - 607

EP - 612

JO - Academic radiology

JF - Academic radiology

IS - 5

ER -

Altered Excitation-inhibition Balance in the Brain of Patients with Diabetic Neuropathy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this