Altered epigenetic patterning leading to replicative senescence and reduced longevity: A role of a novel SNF2 factor, PASG

Lin Quan Sun, Robert J. Arceci

Research output: Contribution to journalShort surveypeer-review

Abstract

Understanding the biological mechanisms underlying aging and cancer predisposition remains a fundamentally important goal in biomedicine. The generation of a PASG hypomorphic mutant mouse model shows that PASG, an SNF2 family member, is essential for properly maintaining normal DNA methylation and gene expression patterns. Disruption of PASG leads to decreased incorporation of BrdU, accumulation of senescence-associated tumor suppressor genes, and increased senescence-associated β-galactosidase as well as age-related phenotypes. These observations demonstrate that PASG plays a critical role in maintenance of tissue homeostasis, normal growth and longevity.

Original languageEnglish (US)
Pages (from-to)3-5
Number of pages3
JournalCell Cycle
Volume4
Issue number1
DOIs
StatePublished - Jan 2005

Keywords

  • Aging
  • Genomic instability
  • Methylation
  • PASG
  • SMARCA6
  • Senescence
  • lsh

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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