Altered dopaminergic function and negative symptoms in drug-free patients with schizophrenia. [123I]-iodobenzamide SPECT study

M. B. Knable, M. F. Egan, A. Heinz, J. Gorey, K. S. Lee, R. Coppola, D. R. Weinberger

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Previous in vivo studies of schizophrenia with dopamine D2 receptor radioligands have yielded contradictory results. No prior study has used multiple scans to examine within-subject clinical change. Method: Twenty-one patients were studied with [123I]-iodobenzamide single photon emission computed tomography about two weeks after neuroleptic withdrawal. Thirteen of the 21 completed a second scan about four weeks after neuroleptic withdrawal. Sixteen controls were scanned for comparison. Results: There was no significant difference between groups in [123I]-iodobenzamide uptake at either scanning session. No significant correlations with demographic variables (age, illness duration, drug-free period), or clinical ratings (positive and negative symptoms, movement disorder) were observed at either scanning session. There was a significant correlation between change in [123I]-iodobenzamide uptake and change in negative symptom ratings for the subjects who underwent two scans (r = 0.72, P < 0.05). Conclusions: Worsening of negative symptoms may be associated with increased availability of striatal D2 receptors, perhaps because of decreased concentrations of endogenous dopamine.

Original languageEnglish (US)
Pages (from-to)574-577
Number of pages4
JournalBritish Journal of Psychiatry
Volume171
Issue numberDEC.
StatePublished - Dec 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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