TY - JOUR
T1 - Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions
T2 - A proton magnetic resonance spectroscopic imaging study
AU - Bertolino, Alessandro
AU - Saunders, Richard C.
AU - Mattay, Venkata S.
AU - Bachevalier, Jocelyne
AU - Frank, Joseph A.
AU - Weinberger, Daniel R.
PY - 1997
Y1 - 1997
N2 - Focal brain damage occurring early in development can have widespread repercussions throughout the developing brain. In living adult rhesus monkeys, we studied the long-term effects of early mesial temporo-limbic (MTL) lesions on prefrontal cortex (PFC) neurons using proton magnetic resonance spectroscopic imaging (1H-MRSI), an in vive neurochemical assay technique for measuring signals from metabolites such as N-acetyl-aspartate (NAA, a neuronal marker), choline-containing compounds (CHO) and creatine + phosphocreatine (CRE). Six monkeys (NL) had undergone surgical ablation of MTL structures within 3 weeks of birth, six monkeys received the some lesion at ~5 years of age and six monkeys were normal controls. We found significant bilateral reductions of NAA relative signals exclusively in the PFC of the NL group in comparison with either of the ether groups. Our results indicate that neonatal MTL damage specifically affects PFC neurons of adult monkeys as indicated by a reduction of NAA. The basis of this effect involves developmental processes as implicated by two arguments: analogous damage during adulthood does not have the same effect; NAA in the healthy brain increases during development. This finding may have implications for understanding developmental aspects of prefrontal-temporolimbic connectivity, and the reduction of NAA levels observed in prefrontal cortex of patients with schizophrenia.
AB - Focal brain damage occurring early in development can have widespread repercussions throughout the developing brain. In living adult rhesus monkeys, we studied the long-term effects of early mesial temporo-limbic (MTL) lesions on prefrontal cortex (PFC) neurons using proton magnetic resonance spectroscopic imaging (1H-MRSI), an in vive neurochemical assay technique for measuring signals from metabolites such as N-acetyl-aspartate (NAA, a neuronal marker), choline-containing compounds (CHO) and creatine + phosphocreatine (CRE). Six monkeys (NL) had undergone surgical ablation of MTL structures within 3 weeks of birth, six monkeys received the some lesion at ~5 years of age and six monkeys were normal controls. We found significant bilateral reductions of NAA relative signals exclusively in the PFC of the NL group in comparison with either of the ether groups. Our results indicate that neonatal MTL damage specifically affects PFC neurons of adult monkeys as indicated by a reduction of NAA. The basis of this effect involves developmental processes as implicated by two arguments: analogous damage during adulthood does not have the same effect; NAA in the healthy brain increases during development. This finding may have implications for understanding developmental aspects of prefrontal-temporolimbic connectivity, and the reduction of NAA levels observed in prefrontal cortex of patients with schizophrenia.
UR - http://www.scopus.com/inward/record.url?scp=0030657626&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030657626&partnerID=8YFLogxK
U2 - 10.1093/cercor/7.8.740
DO - 10.1093/cercor/7.8.740
M3 - Article
C2 - 9408038
AN - SCOPUS:0030657626
SN - 1047-3211
VL - 7
SP - 740
EP - 748
JO - Cerebral Cortex
JF - Cerebral Cortex
IS - 8
ER -