Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium

Research output: Contribution to journalArticle

Abstract

BACKGROUND - The progression of pressure-overload left ventricular hypertrophy (LVH) to chronic heart failure (CHF) may involve a relative deficit in energy supply and/or delivery. METHODS AND RESULTS - We measured myocardial creatine kinase (CK) metabolite concentrations and adenosine triphosphate (ATP) synthesis through CK, the primary energy reserve of the heart, to test the hypothesis that ATP flux through CK is impaired in patients with LVH and CHF. Myocardial ATP levels were normal, but creatine phosphate levels were 35% lower in LVH patients (n=10) than in normal subjects (n=14, P

Original languageEnglish (US)
Pages (from-to)1151-1158
Number of pages8
JournalCirculation
Volume114
Issue number11
DOIs
StatePublished - Sep 2006

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Left Ventricular Hypertrophy
Creatine Kinase
Myocardium
Adenosine Triphosphate
Heart Failure
MB Form Creatine Kinase
Phosphocreatine
Pressure

Keywords

  • Adenosine triphosphate
  • Creatine kinase
  • Heart failure
  • Hypertrophy
  • Magnetic resonance spectroscopy
  • Metabolism

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

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AU - Smith, Craig S.

AU - Bottomley, Paul A

AU - Schulman, Steven P

AU - Gerstenblith, Gary

AU - Weiss, Robert George

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AB - BACKGROUND - The progression of pressure-overload left ventricular hypertrophy (LVH) to chronic heart failure (CHF) may involve a relative deficit in energy supply and/or delivery. METHODS AND RESULTS - We measured myocardial creatine kinase (CK) metabolite concentrations and adenosine triphosphate (ATP) synthesis through CK, the primary energy reserve of the heart, to test the hypothesis that ATP flux through CK is impaired in patients with LVH and CHF. Myocardial ATP levels were normal, but creatine phosphate levels were 35% lower in LVH patients (n=10) than in normal subjects (n=14, P

KW - Adenosine triphosphate

KW - Creatine kinase

KW - Heart failure

KW - Hypertrophy

KW - Magnetic resonance spectroscopy

KW - Metabolism

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