Altered circulating thrombomodulin and fibronectin levels as evidence for different degrees of vascular endothelial damage between severe and mild preeclampsia

C. D. Hsu, T. R B Johnson, S. F. Hong, Daniel Wan-Yui Chan

Research output: Contribution to journalArticle

Abstract

Objective: The purpose of this study is to determine the severity of disease in preeclamptic pregnancies with two circulating endothelial factors, thrombomodulin and fibronectin. Methods: Sixty women with singleton pregnancies in the third trimester were studied. Twenty with mild preeclampsia and 10 with severe preeclampsia were matched with 30 normotensive pregnant women. Maternal serum thrombomodulin and fibronectin levels were measured by enzyme immunoassay and microlatex particle-mediated immunoassay. Results: Serum fibronectin levels were significantly higher in both severely and mildly preeclamptic women than the matched controls (P <0.0005). However, serum thrombomodulin levels were only elevated in severely (P <0.005), but not in mildly preeclamptic groups. Moreover, there was no significant correlation between serum thrombomodulin and fibronectin levels in preeclamptic pregnancies (r = 0.3686, P > 0.05). Conclusions: Elevated serum thrombomodulin and fibronectin levels in pregnant women with preeclampsia provide evidence for the endothelial cell dysfunction in the pathological changes occurring in preeclamptic pregnancies. Circulating thrombomodulin levels may serve as a better marker in differentiating the severity of disease in preeclamptic pregnancies.

Original languageEnglish (US)
Pages (from-to)65-67
Number of pages3
JournalJournal of Maternal-Fetal Investigation
Volume5
Issue number2
StatePublished - 1995
Externally publishedYes

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Thrombomodulin
Pre-Eclampsia
Fibronectins
Blood Vessels
Pregnancy
Pregnant Women
Serum
Third Pregnancy Trimester
Immunoenzyme Techniques
Immunoassay
Endothelial Cells
Mothers

Keywords

  • Endothelial cell damage
  • Fibronectin
  • Preeclampsia
  • Thrombomodulin

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

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title = "Altered circulating thrombomodulin and fibronectin levels as evidence for different degrees of vascular endothelial damage between severe and mild preeclampsia",
abstract = "Objective: The purpose of this study is to determine the severity of disease in preeclamptic pregnancies with two circulating endothelial factors, thrombomodulin and fibronectin. Methods: Sixty women with singleton pregnancies in the third trimester were studied. Twenty with mild preeclampsia and 10 with severe preeclampsia were matched with 30 normotensive pregnant women. Maternal serum thrombomodulin and fibronectin levels were measured by enzyme immunoassay and microlatex particle-mediated immunoassay. Results: Serum fibronectin levels were significantly higher in both severely and mildly preeclamptic women than the matched controls (P <0.0005). However, serum thrombomodulin levels were only elevated in severely (P <0.005), but not in mildly preeclamptic groups. Moreover, there was no significant correlation between serum thrombomodulin and fibronectin levels in preeclamptic pregnancies (r = 0.3686, P > 0.05). Conclusions: Elevated serum thrombomodulin and fibronectin levels in pregnant women with preeclampsia provide evidence for the endothelial cell dysfunction in the pathological changes occurring in preeclamptic pregnancies. Circulating thrombomodulin levels may serve as a better marker in differentiating the severity of disease in preeclamptic pregnancies.",
keywords = "Endothelial cell damage, Fibronectin, Preeclampsia, Thrombomodulin",
author = "Hsu, {C. D.} and Johnson, {T. R B} and Hong, {S. F.} and Chan, {Daniel Wan-Yui}",
year = "1995",
language = "English (US)",
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pages = "65--67",
journal = "Journal of Maternal-Fetal Investigation",
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TY - JOUR

T1 - Altered circulating thrombomodulin and fibronectin levels as evidence for different degrees of vascular endothelial damage between severe and mild preeclampsia

AU - Hsu, C. D.

AU - Johnson, T. R B

AU - Hong, S. F.

AU - Chan, Daniel Wan-Yui

PY - 1995

Y1 - 1995

N2 - Objective: The purpose of this study is to determine the severity of disease in preeclamptic pregnancies with two circulating endothelial factors, thrombomodulin and fibronectin. Methods: Sixty women with singleton pregnancies in the third trimester were studied. Twenty with mild preeclampsia and 10 with severe preeclampsia were matched with 30 normotensive pregnant women. Maternal serum thrombomodulin and fibronectin levels were measured by enzyme immunoassay and microlatex particle-mediated immunoassay. Results: Serum fibronectin levels were significantly higher in both severely and mildly preeclamptic women than the matched controls (P <0.0005). However, serum thrombomodulin levels were only elevated in severely (P <0.005), but not in mildly preeclamptic groups. Moreover, there was no significant correlation between serum thrombomodulin and fibronectin levels in preeclamptic pregnancies (r = 0.3686, P > 0.05). Conclusions: Elevated serum thrombomodulin and fibronectin levels in pregnant women with preeclampsia provide evidence for the endothelial cell dysfunction in the pathological changes occurring in preeclamptic pregnancies. Circulating thrombomodulin levels may serve as a better marker in differentiating the severity of disease in preeclamptic pregnancies.

AB - Objective: The purpose of this study is to determine the severity of disease in preeclamptic pregnancies with two circulating endothelial factors, thrombomodulin and fibronectin. Methods: Sixty women with singleton pregnancies in the third trimester were studied. Twenty with mild preeclampsia and 10 with severe preeclampsia were matched with 30 normotensive pregnant women. Maternal serum thrombomodulin and fibronectin levels were measured by enzyme immunoassay and microlatex particle-mediated immunoassay. Results: Serum fibronectin levels were significantly higher in both severely and mildly preeclamptic women than the matched controls (P <0.0005). However, serum thrombomodulin levels were only elevated in severely (P <0.005), but not in mildly preeclamptic groups. Moreover, there was no significant correlation between serum thrombomodulin and fibronectin levels in preeclamptic pregnancies (r = 0.3686, P > 0.05). Conclusions: Elevated serum thrombomodulin and fibronectin levels in pregnant women with preeclampsia provide evidence for the endothelial cell dysfunction in the pathological changes occurring in preeclamptic pregnancies. Circulating thrombomodulin levels may serve as a better marker in differentiating the severity of disease in preeclamptic pregnancies.

KW - Endothelial cell damage

KW - Fibronectin

KW - Preeclampsia

KW - Thrombomodulin

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