Altered brain structure and function correlate with disease severity and pain catastrophizing in migraine patients

Catherine S. Hubbard, Shariq A. Khan, Michael L. Keaser, David A. Seminowicz, Vani A. Mathur, Madhav Goyal

Research output: Contribution to journalArticle

Abstract

To investigate the neuroanatomical and functional brain changes in migraine patients relative to healthy controls, we used a combined analytical approach including voxel- and surface-based morphometry along with resting-state functional connectivity to determine whether areas showing structural alterations in patients also showed abnormal functional connectivity. Additionally, we wanted to assess whether these structural and functional changes were associated with group differences in pain catastrophizing and migraine-related disease variables in patients. We acquired T1-weighted anatomical and functional magnetic resonance imaging scans during rest in human subjects with a diagnosis of migraine and healthy controls. Structural analyses revealed greater left hippocampal gray matter volume and reduced cortical thickness in the left anterior midcingulate in patients compared with controls. We also observed negative associations between pain catastrophizing and migraine disease variables and gray matter in areas implicated in processing the sensory, affective, and cognitive aspects of pain in patients. Functional connectivity analyses showed that migraine patients displayed disrupted connectivity between default mode, salience, cognitive, visuospatial, and sensorimotor networks, which was associated with group differences in pain catastrophizing and migraine-related disease variables in patients. Together, our findings show widespread morphological and functional brain abnormalities in migraineurs in affective, cognitive, visual, and pain-related brain areas, which are associated with increased pain catastrophizing, disease chronicity, and severity of symptoms, suggesting that these structural and functional changes may be a consequence of repeated, long-term nociceptive signaling leading to increased pain sensitivity, mood disturbances, and mal-adaptive coping strategies to deal with unrelenting pain.

Original languageEnglish (US)
Article numbere.2014
JournaleNeuro
Volume1
Issue number1
DOIs
StatePublished - Nov 1 2014

Fingerprint

Catastrophization
Migraine Disorders
Brain
Pain
Magnetic Resonance Imaging

Keywords

  • Chronic pain
  • Gray matter
  • Headache
  • Intrinsic connectivity
  • Neuroimaging
  • Resting-state networks

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Altered brain structure and function correlate with disease severity and pain catastrophizing in migraine patients. / Hubbard, Catherine S.; Khan, Shariq A.; Keaser, Michael L.; Seminowicz, David A.; Mathur, Vani A.; Goyal, Madhav.

In: eNeuro, Vol. 1, No. 1, e.2014, 01.11.2014.

Research output: Contribution to journalArticle

Hubbard, Catherine S. ; Khan, Shariq A. ; Keaser, Michael L. ; Seminowicz, David A. ; Mathur, Vani A. ; Goyal, Madhav. / Altered brain structure and function correlate with disease severity and pain catastrophizing in migraine patients. In: eNeuro. 2014 ; Vol. 1, No. 1.
@article{9fe4fe984d1a4efb9ea61c74a8e407a6,
title = "Altered brain structure and function correlate with disease severity and pain catastrophizing in migraine patients",
abstract = "To investigate the neuroanatomical and functional brain changes in migraine patients relative to healthy controls, we used a combined analytical approach including voxel- and surface-based morphometry along with resting-state functional connectivity to determine whether areas showing structural alterations in patients also showed abnormal functional connectivity. Additionally, we wanted to assess whether these structural and functional changes were associated with group differences in pain catastrophizing and migraine-related disease variables in patients. We acquired T1-weighted anatomical and functional magnetic resonance imaging scans during rest in human subjects with a diagnosis of migraine and healthy controls. Structural analyses revealed greater left hippocampal gray matter volume and reduced cortical thickness in the left anterior midcingulate in patients compared with controls. We also observed negative associations between pain catastrophizing and migraine disease variables and gray matter in areas implicated in processing the sensory, affective, and cognitive aspects of pain in patients. Functional connectivity analyses showed that migraine patients displayed disrupted connectivity between default mode, salience, cognitive, visuospatial, and sensorimotor networks, which was associated with group differences in pain catastrophizing and migraine-related disease variables in patients. Together, our findings show widespread morphological and functional brain abnormalities in migraineurs in affective, cognitive, visual, and pain-related brain areas, which are associated with increased pain catastrophizing, disease chronicity, and severity of symptoms, suggesting that these structural and functional changes may be a consequence of repeated, long-term nociceptive signaling leading to increased pain sensitivity, mood disturbances, and mal-adaptive coping strategies to deal with unrelenting pain.",
keywords = "Chronic pain, Gray matter, Headache, Intrinsic connectivity, Neuroimaging, Resting-state networks",
author = "Hubbard, {Catherine S.} and Khan, {Shariq A.} and Keaser, {Michael L.} and Seminowicz, {David A.} and Mathur, {Vani A.} and Madhav Goyal",
year = "2014",
month = "11",
day = "1",
doi = "10.1523/ENEURO.0006-14.2014",
language = "English (US)",
volume = "1",
journal = "eNeuro",
issn = "2373-2822",
publisher = "Society for Neuroscience",
number = "1",

}

TY - JOUR

T1 - Altered brain structure and function correlate with disease severity and pain catastrophizing in migraine patients

AU - Hubbard, Catherine S.

AU - Khan, Shariq A.

AU - Keaser, Michael L.

AU - Seminowicz, David A.

AU - Mathur, Vani A.

AU - Goyal, Madhav

PY - 2014/11/1

Y1 - 2014/11/1

N2 - To investigate the neuroanatomical and functional brain changes in migraine patients relative to healthy controls, we used a combined analytical approach including voxel- and surface-based morphometry along with resting-state functional connectivity to determine whether areas showing structural alterations in patients also showed abnormal functional connectivity. Additionally, we wanted to assess whether these structural and functional changes were associated with group differences in pain catastrophizing and migraine-related disease variables in patients. We acquired T1-weighted anatomical and functional magnetic resonance imaging scans during rest in human subjects with a diagnosis of migraine and healthy controls. Structural analyses revealed greater left hippocampal gray matter volume and reduced cortical thickness in the left anterior midcingulate in patients compared with controls. We also observed negative associations between pain catastrophizing and migraine disease variables and gray matter in areas implicated in processing the sensory, affective, and cognitive aspects of pain in patients. Functional connectivity analyses showed that migraine patients displayed disrupted connectivity between default mode, salience, cognitive, visuospatial, and sensorimotor networks, which was associated with group differences in pain catastrophizing and migraine-related disease variables in patients. Together, our findings show widespread morphological and functional brain abnormalities in migraineurs in affective, cognitive, visual, and pain-related brain areas, which are associated with increased pain catastrophizing, disease chronicity, and severity of symptoms, suggesting that these structural and functional changes may be a consequence of repeated, long-term nociceptive signaling leading to increased pain sensitivity, mood disturbances, and mal-adaptive coping strategies to deal with unrelenting pain.

AB - To investigate the neuroanatomical and functional brain changes in migraine patients relative to healthy controls, we used a combined analytical approach including voxel- and surface-based morphometry along with resting-state functional connectivity to determine whether areas showing structural alterations in patients also showed abnormal functional connectivity. Additionally, we wanted to assess whether these structural and functional changes were associated with group differences in pain catastrophizing and migraine-related disease variables in patients. We acquired T1-weighted anatomical and functional magnetic resonance imaging scans during rest in human subjects with a diagnosis of migraine and healthy controls. Structural analyses revealed greater left hippocampal gray matter volume and reduced cortical thickness in the left anterior midcingulate in patients compared with controls. We also observed negative associations between pain catastrophizing and migraine disease variables and gray matter in areas implicated in processing the sensory, affective, and cognitive aspects of pain in patients. Functional connectivity analyses showed that migraine patients displayed disrupted connectivity between default mode, salience, cognitive, visuospatial, and sensorimotor networks, which was associated with group differences in pain catastrophizing and migraine-related disease variables in patients. Together, our findings show widespread morphological and functional brain abnormalities in migraineurs in affective, cognitive, visual, and pain-related brain areas, which are associated with increased pain catastrophizing, disease chronicity, and severity of symptoms, suggesting that these structural and functional changes may be a consequence of repeated, long-term nociceptive signaling leading to increased pain sensitivity, mood disturbances, and mal-adaptive coping strategies to deal with unrelenting pain.

KW - Chronic pain

KW - Gray matter

KW - Headache

KW - Intrinsic connectivity

KW - Neuroimaging

KW - Resting-state networks

UR - http://www.scopus.com/inward/record.url?scp=85046828210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046828210&partnerID=8YFLogxK

U2 - 10.1523/ENEURO.0006-14.2014

DO - 10.1523/ENEURO.0006-14.2014

M3 - Article

AN - SCOPUS:85046828210

VL - 1

JO - eNeuro

JF - eNeuro

SN - 2373-2822

IS - 1

M1 - e.2014

ER -