Abstract
Childhood Maltreatment (CM) is an important risk factor for major depressive disorder (MDD). Previous studies using emotional task-state functional magnetic resonance (task-state fMRI) found that altered brain function in prefrontal-limbic regions was the key neuropathological mechanism in adult MDD patients with experience of early-life maltreatment. However, to the best of our knowledge, there is no published study investigating brain function in MDD patients with CM experience using resting-state fMRI (rs-fMRI). In present study, we aimed to detect altered resting-state brain activity in MDD patients with CM experience, and identify significantly activated brain regions, which may provide new insights into the neural mechanism underlying the relationship between MDD and CM experience. The results showed MDD patients with CM experience were associated with increased amplitude of low-frequency fluctuation (ALFF) and altered function connection (FC) in the prefrontal cortex, when compared to MDD patients without CM. Of note, left frontal middle gyrus (LFEG) was found as a specific brain region which differentiates MDD patients with CM from patients without CM. These results suggest that rs-fMRI is a useful method in studying the correlation between MDD and CM experience and altered function of LFEG in resting-state may explain the correlation between MDD and CM experience.
| Original language | English (US) |
|---|---|
| Article number | 255 |
| Journal | Frontiers in Psychiatry |
| Volume | 10 |
| Issue number | APR |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Childhood maltreatment
- FMRI
- Major depressive disorder
- Prefrontal-limbic system
- Resting state
ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
Altered brain function in drug-naïve major depressive disorder patients with early-life maltreatment : A resting-state fMRI study. / Xu, Zhexue; Zhang, Jing; Wang, Di; Wang, Ting; Zhang, Shu; Ren, Xi; Zhu, Xiaolei; Kamiya, Atsushi; Fang, Jiliang; Qu, Miao.
In: Frontiers in Psychiatry, Vol. 10, No. APR, 255, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Altered brain function in drug-naïve major depressive disorder patients with early-life maltreatment
T2 - A resting-state fMRI study
AU - Xu, Zhexue
AU - Zhang, Jing
AU - Wang, Di
AU - Wang, Ting
AU - Zhang, Shu
AU - Ren, Xi
AU - Zhu, Xiaolei
AU - Kamiya, Atsushi
AU - Fang, Jiliang
AU - Qu, Miao
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Childhood Maltreatment (CM) is an important risk factor for major depressive disorder (MDD). Previous studies using emotional task-state functional magnetic resonance (task-state fMRI) found that altered brain function in prefrontal-limbic regions was the key neuropathological mechanism in adult MDD patients with experience of early-life maltreatment. However, to the best of our knowledge, there is no published study investigating brain function in MDD patients with CM experience using resting-state fMRI (rs-fMRI). In present study, we aimed to detect altered resting-state brain activity in MDD patients with CM experience, and identify significantly activated brain regions, which may provide new insights into the neural mechanism underlying the relationship between MDD and CM experience. The results showed MDD patients with CM experience were associated with increased amplitude of low-frequency fluctuation (ALFF) and altered function connection (FC) in the prefrontal cortex, when compared to MDD patients without CM. Of note, left frontal middle gyrus (LFEG) was found as a specific brain region which differentiates MDD patients with CM from patients without CM. These results suggest that rs-fMRI is a useful method in studying the correlation between MDD and CM experience and altered function of LFEG in resting-state may explain the correlation between MDD and CM experience.
AB - Childhood Maltreatment (CM) is an important risk factor for major depressive disorder (MDD). Previous studies using emotional task-state functional magnetic resonance (task-state fMRI) found that altered brain function in prefrontal-limbic regions was the key neuropathological mechanism in adult MDD patients with experience of early-life maltreatment. However, to the best of our knowledge, there is no published study investigating brain function in MDD patients with CM experience using resting-state fMRI (rs-fMRI). In present study, we aimed to detect altered resting-state brain activity in MDD patients with CM experience, and identify significantly activated brain regions, which may provide new insights into the neural mechanism underlying the relationship between MDD and CM experience. The results showed MDD patients with CM experience were associated with increased amplitude of low-frequency fluctuation (ALFF) and altered function connection (FC) in the prefrontal cortex, when compared to MDD patients without CM. Of note, left frontal middle gyrus (LFEG) was found as a specific brain region which differentiates MDD patients with CM from patients without CM. These results suggest that rs-fMRI is a useful method in studying the correlation between MDD and CM experience and altered function of LFEG in resting-state may explain the correlation between MDD and CM experience.
KW - Childhood maltreatment
KW - FMRI
KW - Major depressive disorder
KW - Prefrontal-limbic system
KW - Resting state
UR - http://www.scopus.com/inward/record.url?scp=85068184078&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068184078&partnerID=8YFLogxK
U2 - 10.3389/fpsyt.2019.00255
DO - 10.3389/fpsyt.2019.00255
M3 - Article
C2 - 31068844
AN - SCOPUS:85068184078
VL - 10
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
SN - 1664-0640
IS - APR
M1 - 255
ER -