Altered brain function in drug-naïve major depressive disorder patients with early-life maltreatment: A resting-state fMRI study

Zhexue Xu, Jing Zhang, Di Wang, Ting Wang, Shu Zhang, Xi Ren, Xiaolei Zhu, Atsushi Kamiya, Jiliang Fang, Miao Qu

Research output: Contribution to journalArticle

Abstract

Childhood Maltreatment (CM) is an important risk factor for major depressive disorder (MDD). Previous studies using emotional task-state functional magnetic resonance (task-state fMRI) found that altered brain function in prefrontal-limbic regions was the key neuropathological mechanism in adult MDD patients with experience of early-life maltreatment. However, to the best of our knowledge, there is no published study investigating brain function in MDD patients with CM experience using resting-state fMRI (rs-fMRI). In present study, we aimed to detect altered resting-state brain activity in MDD patients with CM experience, and identify significantly activated brain regions, which may provide new insights into the neural mechanism underlying the relationship between MDD and CM experience. The results showed MDD patients with CM experience were associated with increased amplitude of low-frequency fluctuation (ALFF) and altered function connection (FC) in the prefrontal cortex, when compared to MDD patients without CM. Of note, left frontal middle gyrus (LFEG) was found as a specific brain region which differentiates MDD patients with CM from patients without CM. These results suggest that rs-fMRI is a useful method in studying the correlation between MDD and CM experience and altered function of LFEG in resting-state may explain the correlation between MDD and CM experience.

Original languageEnglish (US)
Article number255
JournalFrontiers in Psychiatry
Volume10
Issue numberAPR
DOIs
StatePublished - Jan 1 2019

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Major Depressive Disorder
Magnetic Resonance Imaging
Brain
Pharmaceutical Preparations
Prefrontal Cortex
Magnetic Resonance Spectroscopy

Keywords

  • Childhood maltreatment
  • FMRI
  • Major depressive disorder
  • Prefrontal-limbic system
  • Resting state

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Altered brain function in drug-naïve major depressive disorder patients with early-life maltreatment : A resting-state fMRI study. / Xu, Zhexue; Zhang, Jing; Wang, Di; Wang, Ting; Zhang, Shu; Ren, Xi; Zhu, Xiaolei; Kamiya, Atsushi; Fang, Jiliang; Qu, Miao.

In: Frontiers in Psychiatry, Vol. 10, No. APR, 255, 01.01.2019.

Research output: Contribution to journalArticle

Xu, Zhexue ; Zhang, Jing ; Wang, Di ; Wang, Ting ; Zhang, Shu ; Ren, Xi ; Zhu, Xiaolei ; Kamiya, Atsushi ; Fang, Jiliang ; Qu, Miao. / Altered brain function in drug-naïve major depressive disorder patients with early-life maltreatment : A resting-state fMRI study. In: Frontiers in Psychiatry. 2019 ; Vol. 10, No. APR.
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