Altered antisense-to-sense transcript ratios in breast cancer

Reo Maruyama, Michail Shipitsin, Sibgat Choudhury, Zhenhua Wu, Alexei Protopopov, Jun Yao, Pang Kuo Lo, Marina Bessarabova, Alex Ishkin, Yuri Nikolsky, X. Shirley Liu, Saraswati Sukumar, Kornelia Polyak

Research output: Contribution to journalArticle

Abstract

Transcriptome profiling studies suggest that a large fraction of the genome is transcribed and many transcripts function independent of their protein coding potential. The relevance of noncoding RNAs (ncRNAs) in normal physiological processes and in tumorigenesis is increasingly recognized. Here, we describe consistent and significant differences in the distribution of sense and antisense transcripts between normal and neoplastic breast tissues. Many of the differentially expressed antisense transcripts likely represent long ncRNAs. A subset of genes that mainly generate antisense transcripts in normal but not cancer cells is involved in essential metabolic processes. These findings suggest fundamental differences in global RNA regulation between normal and cancer cells that might play a role in tumorigenesis.

Original languageEnglish (US)
Pages (from-to)2820-2824
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume109
Issue number8
DOIs
StatePublished - Feb 21 2012

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Carcinogenesis
Long Noncoding RNA
Breast Neoplasms
Physiological Phenomena
Untranslated RNA
Gene Expression Profiling
Neoplasms
Breast
Genome
RNA
Genes
Proteins

ASJC Scopus subject areas

  • General

Cite this

Maruyama, R., Shipitsin, M., Choudhury, S., Wu, Z., Protopopov, A., Yao, J., ... Polyak, K. (2012). Altered antisense-to-sense transcript ratios in breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 109(8), 2820-2824. https://doi.org/10.1073/pnas.1010559107

Altered antisense-to-sense transcript ratios in breast cancer. / Maruyama, Reo; Shipitsin, Michail; Choudhury, Sibgat; Wu, Zhenhua; Protopopov, Alexei; Yao, Jun; Lo, Pang Kuo; Bessarabova, Marina; Ishkin, Alex; Nikolsky, Yuri; Liu, X. Shirley; Sukumar, Saraswati; Polyak, Kornelia.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 8, 21.02.2012, p. 2820-2824.

Research output: Contribution to journalArticle

Maruyama, R, Shipitsin, M, Choudhury, S, Wu, Z, Protopopov, A, Yao, J, Lo, PK, Bessarabova, M, Ishkin, A, Nikolsky, Y, Liu, XS, Sukumar, S & Polyak, K 2012, 'Altered antisense-to-sense transcript ratios in breast cancer', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 8, pp. 2820-2824. https://doi.org/10.1073/pnas.1010559107
Maruyama, Reo ; Shipitsin, Michail ; Choudhury, Sibgat ; Wu, Zhenhua ; Protopopov, Alexei ; Yao, Jun ; Lo, Pang Kuo ; Bessarabova, Marina ; Ishkin, Alex ; Nikolsky, Yuri ; Liu, X. Shirley ; Sukumar, Saraswati ; Polyak, Kornelia. / Altered antisense-to-sense transcript ratios in breast cancer. In: Proceedings of the National Academy of Sciences of the United States of America. 2012 ; Vol. 109, No. 8. pp. 2820-2824.
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