Alterations of the sympathetic nervous system and metabolic performance of the cardiomyopathic heart

Frank M. Bengel, Bernhard Permanetter, Martin Ungerer, Stephan G. Nekolla, Markus Schwaiger

Research output: Contribution to journalArticle

Abstract

Little is known about the effects of altered sympathetic innervation on the efficiency of the cardio-myopathic heart. Thus, it was the aim of this study to determine non-invasively the relationship between the metabolic cost of cardiac work and alterations of the sympathetic nervous system. In ten patients with chronic idiopathic dilated cardiomyopathy, left ventricular function and geometry were assessed by tomographic radionuclide angiography. Myocardial oxidative metabolism was quantified by the clearance constant k(mono) for carbon-11 acetate, determined by positron emission tomography (PET). Cardiac efficiency was then estimated by the work-metabolic index [WMI = stroke volume index X heart rate X systolic pressure/k(mono)]. Additionally, myocardial presynaptic sympathetic innervation was investigated in the same PET session using 11C-hydroxyephedrine, and plasma norepinephrine levels were determined by high-performance liquid chromatography. The WMI was 3.0±1.3 mmHg × ml × 106/m2 and correlated significantly with left ventricular ejection fraction (19%±10%; r=0.66, P5; r=-0.75, P

Original languageEnglish (US)
Pages (from-to)198-202
Number of pages5
JournalEuropean Journal Of Nuclear Medicine
Volume29
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

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Sympathetic Nervous System
Positron-Emission Tomography
Stroke Volume
Radionuclide Angiography
Dilated Cardiomyopathy
Left Ventricular Function
Norepinephrine
Heart Rate
High Pressure Liquid Chromatography
Blood Pressure
Costs and Cost Analysis
carbon-11 acetate

Keywords

  • Autonomic nervous system
  • Cardiac efficiency
  • Heart failure
  • Positron emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Alterations of the sympathetic nervous system and metabolic performance of the cardiomyopathic heart. / Bengel, Frank M.; Permanetter, Bernhard; Ungerer, Martin; Nekolla, Stephan G.; Schwaiger, Markus.

In: European Journal Of Nuclear Medicine, Vol. 29, No. 2, 2002, p. 198-202.

Research output: Contribution to journalArticle

Bengel, Frank M. ; Permanetter, Bernhard ; Ungerer, Martin ; Nekolla, Stephan G. ; Schwaiger, Markus. / Alterations of the sympathetic nervous system and metabolic performance of the cardiomyopathic heart. In: European Journal Of Nuclear Medicine. 2002 ; Vol. 29, No. 2. pp. 198-202.
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