Alterations of the sympathetic nervous system and metabolic performance of the cardiomyopathic heart

Frank M. Bengel, Bernhard Permanetter, Martin Ungerer, Stephan G. Nekolla, Markus Schwaiger

Research output: Contribution to journalArticlepeer-review

Abstract

Little is known about the effects of altered sympathetic innervation on the efficiency of the cardio-myopathic heart. Thus, it was the aim of this study to determine non-invasively the relationship between the metabolic cost of cardiac work and alterations of the sympathetic nervous system. In ten patients with chronic idiopathic dilated cardiomyopathy, left ventricular function and geometry were assessed by tomographic radionuclide angiography. Myocardial oxidative metabolism was quantified by the clearance constant k(mono) for carbon-11 acetate, determined by positron emission tomography (PET). Cardiac efficiency was then estimated by the work-metabolic index [WMI = stroke volume index X heart rate X systolic pressure/k(mono)]. Additionally, myocardial presynaptic sympathetic innervation was investigated in the same PET session using 11C-hydroxyephedrine, and plasma norepinephrine levels were determined by high-performance liquid chromatography. The WMI was 3.0±1.3 mmHg × ml × 106/m2 and correlated significantly with left ventricular ejection fraction (19%±10%; r=0.66, P<0.04) and peripheral vascular resistance (3,638±1,085 dynes × s/cm5; r=-0.75, P<0.01). Cardiac hydroxyephedrine retention, reflecting integrity of presynaptic innervation, was abnormally low in 58%±38% of the left ventricle. Cardiac hydroxyephedrine retention (r=0.65, P<0.05) and plasma norepinephrine concentration (r=-0.80, P<0.01) both correlated significantly with the WMI. At multivariate stepwise linear regression, only plasma norepinephrine and peripheral vascular resistance were independent determinants of the WMI. In conclusion, metabolic performance of the cardiomyopathic heart decreases with increasing alterations of the sympathetic nervous system. Increasing afterload and effects of systemic sympathetic activation, however, seem to play a dominant role while direct alterations of cardiac presynaptic sympathetic innervation are not independently associated.

Original languageEnglish (US)
Pages (from-to)198-202
Number of pages5
JournalEuropean Journal of Nuclear Medicine
Volume29
Issue number2
DOIs
StatePublished - Feb 23 2002

Keywords

  • Autonomic nervous system
  • Cardiac efficiency
  • Heart failure
  • Positron emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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