Alterations of L- and M-cone driven ERGs in cone and cone-rod dystrophies

Hendrik P.N. Scholl, Jan Kremers

Research output: Contribution to journalArticle

Abstract

To study the L- and M-cone pathways and their interactions in patients with cone and cone-rod dystrophies, ERG responses were measured to stimuli which modulated exclusively the L- or the M-cones, or the two simultaneously. The L- and M-cone driven ERG amplitudes were considerably reduced in the patients. The mean phases of the L-cone driven ERGs in the patients lagged those of normals significantly, whereas the mean M-cone driven ERGs were significantly phase advanced resulting in a substantial phase difference between the two ERG responses. These phase changes in the L- and M-cone driven responses in the patients cannot be detected with standard ERG techniques.

Original languageEnglish (US)
Pages (from-to)2333-2344
Number of pages12
JournalVision Research
Volume43
Issue number22
DOIs
StatePublished - Oct 2003

Keywords

  • Cone dystrophy
  • Cone-rod dystrophy
  • Electroretinography
  • L-cones
  • M-cones

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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