Abstract
To study the L- and M-cone pathways and their interactions in patients with cone and cone-rod dystrophies, ERG responses were measured to stimuli which modulated exclusively the L- or the M-cones, or the two simultaneously. The L- and M-cone driven ERG amplitudes were considerably reduced in the patients. The mean phases of the L-cone driven ERGs in the patients lagged those of normals significantly, whereas the mean M-cone driven ERGs were significantly phase advanced resulting in a substantial phase difference between the two ERG responses. These phase changes in the L- and M-cone driven responses in the patients cannot be detected with standard ERG techniques.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2333-2344 |
| Number of pages | 12 |
| Journal | Vision Research |
| Volume | 43 |
| Issue number | 22 |
| DOIs | |
| State | Published - Oct 2003 |
Keywords
- Cone dystrophy
- Cone-rod dystrophy
- Electroretinography
- L-cones
- M-cones
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
Fingerprint Dive into the research topics of 'Alterations of L- and M-cone driven ERGs in cone and cone-rod dystrophies'. Together they form a unique fingerprint.
Cite this
Scholl, H. P. N., & Kremers, J. (2003). Alterations of L- and M-cone driven ERGs in cone and cone-rod dystrophies. Vision Research, 43(22), 2333-2344. https://doi.org/10.1016/S0042-6989(03)00411-5