Abstract
To study the L- and M-cone pathways and their interactions in patients with cone and cone-rod dystrophies, ERG responses were measured to stimuli which modulated exclusively the L- or the M-cones, or the two simultaneously. The L- and M-cone driven ERG amplitudes were considerably reduced in the patients. The mean phases of the L-cone driven ERGs in the patients lagged those of normals significantly, whereas the mean M-cone driven ERGs were significantly phase advanced resulting in a substantial phase difference between the two ERG responses. These phase changes in the L- and M-cone driven responses in the patients cannot be detected with standard ERG techniques.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2333-2344 |
| Number of pages | 12 |
| Journal | Vision Research |
| Volume | 43 |
| Issue number | 22 |
| DOIs | |
| State | Published - Oct 2003 |
| Externally published | Yes |
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Keywords
- Cone dystrophy
- Cone-rod dystrophy
- Electroretinography
- L-cones
- M-cones
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
Cite this
Alterations of L- and M-cone driven ERGs in cone and cone-rod dystrophies. / Scholl, Hendrik P N; Kremers, Jan.
In: Vision Research, Vol. 43, No. 22, 10.2003, p. 2333-2344.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alterations of L- and M-cone driven ERGs in cone and cone-rod dystrophies
AU - Scholl, Hendrik P N
AU - Kremers, Jan
PY - 2003/10
Y1 - 2003/10
N2 - To study the L- and M-cone pathways and their interactions in patients with cone and cone-rod dystrophies, ERG responses were measured to stimuli which modulated exclusively the L- or the M-cones, or the two simultaneously. The L- and M-cone driven ERG amplitudes were considerably reduced in the patients. The mean phases of the L-cone driven ERGs in the patients lagged those of normals significantly, whereas the mean M-cone driven ERGs were significantly phase advanced resulting in a substantial phase difference between the two ERG responses. These phase changes in the L- and M-cone driven responses in the patients cannot be detected with standard ERG techniques.
AB - To study the L- and M-cone pathways and their interactions in patients with cone and cone-rod dystrophies, ERG responses were measured to stimuli which modulated exclusively the L- or the M-cones, or the two simultaneously. The L- and M-cone driven ERG amplitudes were considerably reduced in the patients. The mean phases of the L-cone driven ERGs in the patients lagged those of normals significantly, whereas the mean M-cone driven ERGs were significantly phase advanced resulting in a substantial phase difference between the two ERG responses. These phase changes in the L- and M-cone driven responses in the patients cannot be detected with standard ERG techniques.
KW - Cone dystrophy
KW - Cone-rod dystrophy
KW - Electroretinography
KW - L-cones
KW - M-cones
UR - http://www.scopus.com/inward/record.url?scp=0041378211&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041378211&partnerID=8YFLogxK
U2 - 10.1016/S0042-6989(03)00411-5
DO - 10.1016/S0042-6989(03)00411-5
M3 - Article
C2 - 12962990
AN - SCOPUS:0041378211
VL - 43
SP - 2333
EP - 2344
JO - Vision Research
JF - Vision Research
SN - 0042-6989
IS - 22
ER -