Alterations in soluble intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in hemodialysis patients

H. Rabb, E. Calderon, P. A. Bittle, G. Ramirez

Research output: Contribution to journalArticlepeer-review


Hemodialysis (HD) patients can develop acute reactions during treatment as well as increased long-term susceptibility to infections and malignancies. Abnormalities in leukocyte adhesion may contribute to these processes. Recently, serum levels of soluble adhesion molecules have been detected in circulating blood of normal subjects and in patients with chronic renal failure. We studied the effects of a single dialysis session with new cuprophane membrane on the soluble (s) form of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), two adhesion molecules with a variety of immunologic roles. Significant elevations in both sICAM-1 (523 ± 61 v 304 ± 45 [SEM] ng/mL, P < 0.05) end sVCAM-1 (2,055 ± 270 v 1,189 ± 149 ng/mL, P < 0.05) were observed in HD patients at baseline compared with controls. Both sICAM-1 and sVCAM-1 levels decreased after a 3-hour HD session (P < 0.001). Early in HD, sICAM-1 levels, though lower then predialysis, were elevated in the exit line of the dialyzer compared with entrance (339 ± 64 v 259 ± 53 ng/mL, P < 0.001), whereas sVCAM-1 was decreased on the exit line compared with entrance (639 ± 90 v 932 ± 92 ng/mL, P < 0.001). Because ICAM-1 and VCAM-1 are important for many leukocyte functions, alterations in serum levels of sICAM-1 and sVCAM-1 may play a role in the immunologic consequences of uremia and HD treatment.

Original languageEnglish (US)
Pages (from-to)239-243
Number of pages5
JournalAmerican Journal of Kidney Diseases
Issue number2
StatePublished - 1996
Externally publishedYes


  • Kidney failure
  • hemodialysis
  • intercellular adhesion molecule-1
  • soluble receptors
  • vascular cell adhesion molecule-1

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'Alterations in soluble intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in hemodialysis patients'. Together they form a unique fingerprint.

Cite this