TY - JOUR
T1 - Alterations in soluble intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in hemodialysis patients
AU - Rabb, H.
AU - Calderon, E.
AU - Bittle, P. A.
AU - Ramirez, G.
N1 - Funding Information:
Dr Rabb is a recipient of a University of South Florida (Tampa, FL) Creative Scholars Award and a National Kidney Foundation (New York, NY) Young Investigator Award.
PY - 1996
Y1 - 1996
N2 - Hemodialysis (HD) patients can develop acute reactions during treatment as well as increased long-term susceptibility to infections and malignancies. Abnormalities in leukocyte adhesion may contribute to these processes. Recently, serum levels of soluble adhesion molecules have been detected in circulating blood of normal subjects and in patients with chronic renal failure. We studied the effects of a single dialysis session with new cuprophane membrane on the soluble (s) form of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), two adhesion molecules with a variety of immunologic roles. Significant elevations in both sICAM-1 (523 ± 61 v 304 ± 45 [SEM] ng/mL, P < 0.05) end sVCAM-1 (2,055 ± 270 v 1,189 ± 149 ng/mL, P < 0.05) were observed in HD patients at baseline compared with controls. Both sICAM-1 and sVCAM-1 levels decreased after a 3-hour HD session (P < 0.001). Early in HD, sICAM-1 levels, though lower then predialysis, were elevated in the exit line of the dialyzer compared with entrance (339 ± 64 v 259 ± 53 ng/mL, P < 0.001), whereas sVCAM-1 was decreased on the exit line compared with entrance (639 ± 90 v 932 ± 92 ng/mL, P < 0.001). Because ICAM-1 and VCAM-1 are important for many leukocyte functions, alterations in serum levels of sICAM-1 and sVCAM-1 may play a role in the immunologic consequences of uremia and HD treatment.
AB - Hemodialysis (HD) patients can develop acute reactions during treatment as well as increased long-term susceptibility to infections and malignancies. Abnormalities in leukocyte adhesion may contribute to these processes. Recently, serum levels of soluble adhesion molecules have been detected in circulating blood of normal subjects and in patients with chronic renal failure. We studied the effects of a single dialysis session with new cuprophane membrane on the soluble (s) form of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), two adhesion molecules with a variety of immunologic roles. Significant elevations in both sICAM-1 (523 ± 61 v 304 ± 45 [SEM] ng/mL, P < 0.05) end sVCAM-1 (2,055 ± 270 v 1,189 ± 149 ng/mL, P < 0.05) were observed in HD patients at baseline compared with controls. Both sICAM-1 and sVCAM-1 levels decreased after a 3-hour HD session (P < 0.001). Early in HD, sICAM-1 levels, though lower then predialysis, were elevated in the exit line of the dialyzer compared with entrance (339 ± 64 v 259 ± 53 ng/mL, P < 0.001), whereas sVCAM-1 was decreased on the exit line compared with entrance (639 ± 90 v 932 ± 92 ng/mL, P < 0.001). Because ICAM-1 and VCAM-1 are important for many leukocyte functions, alterations in serum levels of sICAM-1 and sVCAM-1 may play a role in the immunologic consequences of uremia and HD treatment.
KW - Kidney failure
KW - hemodialysis
KW - intercellular adhesion molecule-1
KW - soluble receptors
KW - vascular cell adhesion molecule-1
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U2 - 10.1016/S0272-6386(96)90547-8
DO - 10.1016/S0272-6386(96)90547-8
M3 - Article
C2 - 8659500
AN - SCOPUS:0030041901
SN - 0272-6386
VL - 27
SP - 239
EP - 243
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 2
ER -